Granisetron Hcl Injection

  • Nausea

Granisetron Hcl Injection Generic Name & Formulations

General Description

Granisetron (as HCl) 1mg/mL (contains benzyl alcohol); 0.1mg/mL (preservative-free); IV inj.

Pharmacological Class

Selective 5-HT3 receptor antagonist.

How Supplied

Contact supplier.

Granisetron Hcl Injection Indications


Prevention of nausea and vomiting associated with chemotherapy (including high-dose cisplatin). Prevention and treatment of post-op nausea and vomiting.

Granisetron Hcl Injection Dosage and Administration

Adults and Children

Chemotherapy: give as an undiluted IV injection over 30 seconds or as a diluted IV infusion over 5 minutes. <2 years: not recommended; ≥2 years: 10micrograms/kg starting within 30 minutes of initiating chemotherapy, only on the days chemotherapy is given. Post-op (adults): infuse 1mg undiluted IV over 30 seconds. For prevention, give before induction of anesthesia or immediately before reversal of anesthesia. Post-op (children): not recommended.

Granisetron Hcl Injection Contraindications

Not Applicable

Granisetron Hcl Injection Boxed Warnings

Not Applicable

Granisetron Hcl Injection Warnings/Precautions


Abdominal surgery. May mask progressive ileus and/or gastric distention. Pre-existing arrhythmias or cardiac conduction disorders. Cardiac disease, concomitant cardio-toxic chemotherapy or electrolyte abnormalities: increased risk of QT prolongation. Pregnancy (Cat.B). Nursing mothers.

Granisetron Hcl Injection Pharmacokinetics

See Literature

Granisetron Hcl Injection Interactions


Caution with drugs that affect CYP450 or prolong the QT interval.

Granisetron Hcl Injection Adverse Reactions

Adverse Reactions

Headache, asthenia, diarrhea, constipation; QT prolongation.

Granisetron Hcl Injection Clinical Trials

See Literature

Granisetron Hcl Injection Note


Formerly known under the brand name Kytril.

Granisetron Hcl Injection Patient Counseling

See Literature