Granisetron Hcl Injection Generic Name & Formulations
Granisetron (as HCl) 1mg/mL (contains benzyl alcohol); 0.1mg/mL (preservative-free); IV inj.
Selective 5-HT3 receptor antagonist.
Granisetron Hcl Injection Indications
Prevention of nausea and vomiting associated with chemotherapy (including high-dose cisplatin). Prevention and treatment of post-op nausea and vomiting.
Granisetron Hcl Injection Dosage and Administration
Adults and Children
Chemotherapy: give as an undiluted IV injection over 30 seconds or as a diluted IV infusion over 5 minutes. <2 years: not recommended; ≥2 years: 10micrograms/kg starting within 30 minutes of initiating chemotherapy, only on the days chemotherapy is given. Post-op (adults): infuse 1mg undiluted IV over 30 seconds. For prevention, give before induction of anesthesia or immediately before reversal of anesthesia. Post-op (children): not recommended.
Granisetron Hcl Injection Contraindications
Granisetron Hcl Injection Boxed Warnings
Granisetron Hcl Injection Warnings/Precautions
Abdominal surgery. May mask progressive ileus and/or gastric distention. Pre-existing arrhythmias or cardiac conduction disorders. Cardiac disease, concomitant cardio-toxic chemotherapy or electrolyte abnormalities: increased risk of QT prolongation. Pregnancy (Cat.B). Nursing mothers.
Granisetron Hcl Injection Pharmacokinetics
Granisetron Hcl Injection Interactions
Caution with drugs that affect CYP450 or prolong the QT interval.
Granisetron Hcl Injection Adverse Reactions
Headache, asthenia, diarrhea, constipation; QT prolongation.
Granisetron Hcl Injection Clinical Trials
Granisetron Hcl Injection Note
Formerly known under the brand name Kytril.
Granisetron Hcl Injection Patient Counseling