• Nonnarcotic analgesics

Gralise Generic Name & Formulations

General Description

Gabapentin 300mg, 600mg; tabs.

How Supplied

Tabs—90; 30-Day Starter pack—78 (9 x 300mg + 69 x 600mg)


Gralise Indications


Postherpetic neuralgia.

Gralise Dosage and Administration


Swallow whole; do not crush, split or chew tabs. Take once daily with the evening meal. ≥18yrs: initially 300mg on Day 1, 600mg on Day 2, 900mg on Days 3–6, 1200mg on Days 7–10, 1500mg on Days 11–14, titrate up to 1800mg on Day 15. Renal impairment: CrCl 30–60mL/min: 600–1800mg. CrCl <30mL/min or on hemodialysis: not recommended.


<18yrs: not established.

Gralise Contraindications

Not Applicable

Gralise Boxed Warnings

Not Applicable

Gralise Warnings/Precautions


Not interchangeable with other gabapentin products. Epilepsy. Increased risk of suicidal thoughts/behavior. Monitor for worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. Multiorgan hypersensitivity. Renal impairment. Avoid abrupt cessation; if discontinuing, withdraw gradually over 1 week or longer. Elderly. Pregnancy (Cat.C). Nursing mothers.

Gralise Pharmacokinetics

See Literature

Gralise Interactions


Increased risk for serious respiratory depression when concomitant CNS depressants, opioids. May affect or be affected by hydrocodone. Potentiated by morphine. Separate dosing of aluminum- or magnesium-containing antacids by at least 2hrs. May cause false (+) results with urine protein tests (eg, Multistix SG).

Gralise Adverse Reactions

Adverse Reactions

Dizziness, somnolence, headache, lethargy, peripheral edema, diarrhea, dry mouth, pain in extremity.

Gralise Clinical Trials

See Literature

Gralise Note

Not Applicable

Gralise Patient Counseling

See Literature