Indications for: GRALISE
Swallow whole; do not crush, split or chew tabs. Take once daily with the evening meal. ≥18yrs: initially 300mg on Day 1, 600mg on Day 2, 900mg on Days 3–6, 1200mg on Days 7–10, 1500mg on Days 11–14, titrate up to 1800mg on Day 15. Renal impairment: CrCl 30–60mL/min: 600–1800mg. CrCl <30mL/min or on hemodialysis: not recommended.
<18yrs: not established.
Not interchangeable with other gabapentin products. Epilepsy. Increased risk of suicidal thoughts/behavior. Monitor for worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. Multiorgan hypersensitivity. Renal impairment. Avoid abrupt cessation; if discontinuing, withdraw gradually over 1 week or longer. Elderly. Pregnancy (Cat.C). Nursing mothers.
Increased risk for serious respiratory depression when concomitant CNS depressants, opioids. May affect or be affected by hydrocodone. Potentiated by morphine. Separate dosing of aluminum- or magnesium-containing antacids by at least 2hrs. May cause false (+) results with urine protein tests (eg, Multistix SG).
Dizziness, somnolence, headache, lethargy, peripheral edema, diarrhea, dry mouth, pain in extremity.
Tabs—90; 30-Day Starter pack—78 (9 x 300mg + 69 x 600mg)