Constipation and bowel cleansers:
Indications for GoLYTELY:
Bowel cleansing before colonscopy and barium enema x-ray examination.
Adult:
May consume water or clear liquids during and after completion of bowel prep up until 2hrs before procedure. Drink 240mL orally every 10 mins or 20–30mL/min by NG tube until rectal effluent is clear or 1 gallon consumed. May interrupt if severe GI disturbances occur.
Children:
Not established.
Contraindications:
GI obstruction. Bowel perforation. Gastric retention. Ileus. Toxic colitis or megacolon.
Warnings/Precautions:
Not for direct ingestion. Correct fluid/electrolyte abnormalities before use. History of prolonged QT, uncontrolled arrhythmias, recent MI, unstable angina, CHF, or cardiomyopathy: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. History or risk of seizures. Renal impairment; monitor baseline and post-colonoscopy electrolytes, creatinine, BUN. Inflammatory bowel disease. Rule out suspected GI obstruction/perforation before administering. Severe ulcerative colitis. Impaired gag reflex. Semi- or unconscious patients. Risk of regurgitation or aspiration. Maintain adequate hydration. Pregnancy (Cat.C). Nursing mothers.
Pharmacologic Class:
Isosmotic bowel cleanser.
Interactions:
Caution with drugs that increase risk of fluid/electrolyte abnormalities, arrhythmias or QT prolongation. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Avoid concomitant stimulant laxatives (eg, bisacodyl, sodium picosulfate). Oral drugs administered within 1hr of start of Golytely may not be absorbed.
Adverse Reactions:
Nausea, abdominal fullness and bloating, cramps, vomiting, anal irritation; seizures, arrhythmias, mucosal ulcerations and ischemic colitis.
How Supplied:
Disposable jug (4L)—1; Packet (to make 4L)—1
