Glynase Prestab

  • Diabetes

Glynase Prestab Generic Name & Formulations

General Description

Glyburide, micronized 1.5mg, 3mg, 6mg; scored tabs.

Pharmacological Class

Sulfonylurea (2nd generation).

How Supplied

PresTab 1.5mg—100; 3mg—100, 500, 1000; 6mg—100, 500


Glynase Prestab Indications


Adjunct to diet and exercise in type 2 diabetes.

Glynase Prestab Dosage and Administration


Initially 1.5–3mg daily with breakfast. Debilitated: initially 0.75mg daily with breakfast. Increase by 1.5mg at weekly intervals if needed per blood glucose. Maintenance: 0.75–12mg daily in single or divided doses (consider divided doses above 6mg daily); max 12mg daily.


Not established.

Glynase Prestab Contraindications


Diabetic ketoacidosis, with or without coma. Type 1 diabetes. Concomitant bosentan.

Glynase Prestab Boxed Warnings

Not Applicable

Glynase Prestab Warnings/Precautions


Increased risk of cardiovascular mortality. Impaired renal or hepatic function. Stress. Secondary failure may occur with extended therapy. Discontinue if jaundice or persistent rash occurs. G6PD deficiency; consider non-sulfonylurea alternative. Monitor urine, blood glucose, and glycosylated hemoglobin. Retitrate if transfer from other glyburide containing or hypoglycemic agents (see full labeling). Elderly, debilitated, malnourished, adrenal or pituitary insufficiency, severe/prolonged exercise: increased risk of hypoglycemia. Pregnancy (Cat.B): consider using insulin instead; if glyburide needed, discontinue ≥2 weeks before delivery date. Nursing mothers: not recommended.

Glynase Prestab Pharmacokinetics

See Literature

Glynase Prestab Interactions


Elevated liver enzymes with concomitant bosentan (see Contraindications). Increased risk of hypoglycemia with concomitant alcohol or other hypoglycemics. Potentiated by NSAIDs, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, β-blockers. Antagonized by diuretics, steroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, niacin, sympathomimetics, calcium channel blockers and isoniazid. May be potentiated by ciprofloxacin, oral miconazole. Administer glyburide >4hrs prior to colesevelam. Disulfiram-like reaction with alcohol (rare). Monitor for 2 weeks if transferring from chlorpropamide.

Glynase Prestab Adverse Reactions

Adverse Reactions

Hypoglycemia, cholestatic jaundice (rare), nausea, epigastric fullness, heartburn, allergic skin reactions, photosensitivity, blood dyscrasias, hepatic porphyria, hyponatremia.

Glynase Prestab Clinical Trials

See Literature

Glynase Prestab Note

Not Applicable

Glynase Prestab Patient Counseling

See Literature