• Diabetes

Glyburide Generic Name & Formulations

General Description

Glyburide 1.25mg, 2.5mg, 5mg; scored tabs.

Pharmacological Class

Sulfonylurea (2nd generation).

How Supplied

Contact supplier

Glyburide Indications


Adjunct to diet and exercise in type 2 diabetes mellitus.

Glyburide Dosage and Administration


Initially 2.5–5mg daily with breakfast or first main meal. Elderly or debilitated: initially 1.25mg daily. Increase by 2.5mg at weekly intervals if needed per blood glucose. Maintenance: 1.25–20mg daily in single or divided doses (consider divided doses above 10mg daily); max 20mg daily.


Not established.

Glyburide Contraindications


Type 1 diabetes or diabetic ketoacidosis with or without coma. Concomitant bosentan.

Glyburide Boxed Warnings

Not Applicable

Glyburide Warnings/Precautions


Oral hypoglycemic agents may increase risk of cardiovascular mortality. Renal or hepatic impairment. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with extended therapy. Risk of hemolytic anemia in G6PD deficiency; consider non-sulfonylurea alternative. Monitor urine, fasting blood glucose, and HbA1c levels periodically. Discontinue if jaundice or hepatitis occurs. Sulfonamide allergy. Malnourished. Elderly. Debilitated. Pregnancy (Cat.C): consider using insulin instead. Nursing mothers: not recommended.

Glyburide Pharmacokinetics

See Literature

Glyburide Interactions


See Contraindications. May be potentiated by NSAIDs, ACEIs, disopyramide, fluoxetine, clarithromycin, coumarin, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, MAOIs, β-blockers, oral miconazole (possibly), fluroquinolones. Antagonized by diuretics, steroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, niacin, sympathomimetics, calcium channel blockers, isoniazid. Monitor closely for hypoglycemia with concomitant drugs that affect glucose metabolism and upon withdrawal. May increase cyclosporine levels; monitor and adjust cyclosporine dose. Caution with CYP2C9 inhibitors or inducers (eg, rifampin). May be antagonized by topiramate, colesevelam; administer glyburide ≥4hrs prior to colesevelam. Disulfiram-like reaction with alcohol (rare). Monitor for 2 weeks if transferring from chlorpropamide.

Glyburide Adverse Reactions

Adverse Reactions

Hypoglycemia, nausea, epigastric fullness, heartburn, allergic skin reactions, photosensitivity, blood dyscrasias; rare: cholestatic jaundice, hepatitis.

Glyburide Clinical Trials

See Literature

Glyburide Note


Formerly known under the brand name Diabeta.

Glyburide Patient Counseling

See Literature