Glucotrol Xl Generic Name & Formulations
Glipizide 2.5mg, 5mg, 10mg; ext-rel tabs.
Sulfonylurea (2nd generation).
XL tabs 2.5mg—30; 5mg, 10mg—100, 500; Tabs—contact supplier
Glucotrol Xl Indications
Adjunct to diet and exercise in type 2 diabetes mellitus. Limitations of use: not for treating type 1 diabetes or diabetic ketoacidosis.
Limitations of Use
Not for treating type 1 diabetes or diabetic ketoacidosis.
Glucotrol Xl Dosage and Administration
Swallow whole. Initially 5mg daily with breakfast. Usual range: 5–10mg once daily; max 20mg daily. Elderly, renal or hepatic impairment: initially 2.5mg. Concomitant other hypoglycemics or transferring to Glucotrol XL: see full labeling.
Glucotrol Xl Contraindications
Type 1 diabetes, diabetic ketoacidosis, with or without coma. Sulfonamide allergy.
Glucotrol Xl Boxed Warnings
Glucotrol Xl Warnings/Precautions
Increased risk of cardiovascular mortality. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with extended therapy. Risk of hemolytic anemia in G6PD deficiency; consider non-sulfonylurea alternative. Monitor urine and blood glucose. Impaired GI function or GI narrowing (XL); avoid. Discontinue if jaundice occurs or skin reactions persist. Elderly, debilitated, uncompensated strenuous exercise, malnourished or deficient caloric intake, adrenal or pituitary insufficiency, or alcohol intoxication: increased risk of hypoglycemia. Renal or hepatic impairment (see Adults). Neonates. Pregnancy: discontinue at least 2 weeks before expected delivery. Nursing mothers: monitor infants for hypoglycemia.
Glucotrol Xl Pharmacokinetics
Glucotrol Xl Interactions
May be potentiated by concomitant oral miconazole, fluconazole, or drugs affecting glucose metabolism (eg, ACEIs, ARBs, NSAIDs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, quinolones); monitor closely for hypoglycemia with co-administration and for worsening glycemic control upon withdrawal (see full labeling). May be antagonized by atypical antipsychotics, diuretics, steroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, niacin, sympathomimetics, calcium channel blockers, isoniazid, protease inhibitors; monitor. May be antagonized by colesevelam; administer glipizide ≥4hrs prior to colesevelam. β-blockers, clonidine, guanethidine, reserpine may mask hypoglycemia. Disulfiram-like reaction with alcohol (rare). Monitor for 1–2 weeks if transferring from long-acting sulfonylureas.
Glucotrol Xl Adverse Reactions
Hypoglycemia, tremor, asthenia, diarrhea, flatulence, allergic skin reactions, photosensitivity, blood dyscrasias, hyponatremia, dizziness, drowsiness, headache; rare: cholestatic jaundice, hepatic porphyria.
Glucotrol Xl Clinical Trials
Glucotrol Xl Note
Glucotrol Xl Patient Counseling