• CNS cancers

Gliadel Generic Name & Formulations

General Description

Carmustine 7.7mg, polifeprosan 20; per wafer.

Pharmacological Class


How Supplied

Single-dose treatment box (8 wafers)—1

Gliadel Indications


Newly-diagnosed high-grade malignant glioma as an adjunct to surgery and radiation. Recurrent glioblastoma multiforme as an adjunct to surgery.

Gliadel Dosage and Administration


See literature. Place 8 wafers (61.6mg) in the resection cavity if the size and shape of it allows; max 8 wafers per surgical procedure.


Not recommended.

Gliadel Contraindications

Not Applicable

Gliadel Boxed Warnings

Not Applicable

Gliadel Warnings/Precautions


Avoid communication between surgical resection cavity and ventricular system to prevent wafer from migrating and causing obstructive hydrocephalus. If communication larger than diameter of wafer exists, it should be closed prior to wafer implantation. Pregnancy (Cat.D). Nursing mothers: not recommended.

Gliadel Pharmacokinetics

See Literature

Gliadel Interactions

Gliadel Adverse Reactions

Adverse Reactions

Abdominal pain, back pain, chest pain, intracranial hypertension, abnormal healing, brain edema, meningitis or abscess; intracerebral mass effect.

Gliadel Clinical Trials

See Literature

Gliadel Note

Not Applicable

Gliadel Patient Counseling

See Literature