Indications for GIAPREZA:
To increase blood pressure in septic or other distributive shock.
Give by IV infusion. Initially 20ng/kg/min. May titrate every 5mins by increments of up to 15ng/kg/min as needed based on BP response; max 80ng/kg/min during first 3hrs of treatment. Maintenance dose: max 40ng/kg/min. Doses as low as 1.25ng/kg/min may be used. Once sufficiently improved, down-titrate every 5–15mins by increments of up to 15ng/kg/min based on BP.
Risk of thrombosis. Use concurrent VTE prophylaxis. Pregnancy. Nursing mothers.
Concomitant ACE inhibitors may increase response. Concomitant ARBs may decrease response.
Thromboembolic events (eg, deep vein thrombosis), thrombocytopenia, tachycardia, fungal infection, delirium, acidosis, hyperglycemia, peripheral ischemia.
Generic Drug Availability:
Single-dose vial (1mL, 2mL)—1