Giapreza Generic Name & Formulations
Angiotensin II 2.5mg/mL; per vial; soln for IV infusion after dilution.
Single-dose vial (1mL, 2mL)—1
To increase blood pressure in septic or other distributive shock.
Giapreza Dosage and Administration
Give by IV infusion. Initially 20ng/kg/min. May titrate every 5mins by increments of up to 15ng/kg/min as needed based on BP response; max 80ng/kg/min during first 3hrs of treatment. Maintenance dose: max 40ng/kg/min. Doses as low as 1.25ng/kg/min may be used. Once sufficiently improved, down-titrate every 5–15mins by increments of up to 15ng/kg/min based on BP.
Giapreza Boxed Warnings
Risk of thrombosis. Use concurrent VTE prophylaxis. Pregnancy. Nursing mothers.
Concomitant ACE inhibitors may increase response. Concomitant ARBs may decrease response.
Giapreza Adverse Reactions
Thromboembolic events (eg, deep vein thrombosis), thrombocytopenia, tachycardia, fungal infection, delirium, acidosis, hyperglycemia, peripheral ischemia.
Giapreza Clinical Trials
Giapreza Patient Counseling