Gammaked

See full labeling. Individualize. Give as IV infusion only. 2g/kg, divided in 2 doses of 1g/kg given on 2 consecutive days (may withhold 2^nd dose if adequate platelet increase at 24hrs) or into 5 doses of 0.4g/kg given on 5 consecutive days. Initial infusion rate: 1mg/kg/min; may gradually increase to max 8mg/kg/min if tolerated. Expanded fluid volume or fluid volume concern: 1g/kg regimen not recommended. Risk for renal dysfunction/failure or thrombosis: give at the minimum infusion rate practicable.

See full labeling. Individualize. Primary immunodeficiency (PI): <2yrs: not established. ≥2yrs: IV infusion: 300–600mg/kg every 3–4 weeks. Initial infusion rate: 1mg/kg/min; may gradually increase to max 8mg/kg/min if tolerated. Risk of measles exposure with routine dose of <400mg/kg every 3–4 weeks: give at least 400mg/kg dose just prior to expected exposure; if exposed, give 400mg/kg dose as soon as possible. SC infusion: give by using an infusion pump into abdomen, thigh, upper arm, and/or lateral hip areas. May use up to 6 (children) or 8 (adults) infusion sites (at least 2 inches apart) simultaneously. Obtain serum IgG trough level to guide subsequent dose adjustments. Start 1 week after last IGIV infusion. Initial weekly dose: 1.37 x previous IGIV dose (in grams)/number of weeks between IGIV doses. Infusion rate: adults: 20mL/hr/site; children/adolescents (if <25kg): 10mL/hr/site; (if ≥25kg): initially 15mL/hr/site, then increase up to 20mL/hr/site. Dose adjustments: see full labeling. CIDP: children: not established. Give as IV infusion only. Adults: initially 2g/kg loading dose divided over 2–4 consecutive days. May be administered as a maintenance infusion: 1g/kg given over 1 day or divided in 2 doses of 0.5g/kg given on 2 consecutive days, every 3 weeks. Initial infusion rate: 2mg/kg/min; may increase to max 8mg/kg/min if tolerated. For PI (IV regimen), CIDP: if risk for renal dysfunction/failure or thrombosis, give at the minimum infusion rate practicable.