• Alzheimer's dementia

Galantamine Generic Name & Formulations

General Description

Galantamine (as HBr) 4mg, 8mg, 12mg; tabs.

Pharmacological Class

Reversible acetylcholinesterase inhibitor (benzazepine deriv).

How Supplied

Tabs, soln—contact supplier; ER caps—30

Galantamine Indications


Mild to moderate Alzheimer's dementia.

Galantamine Dosage and Administration


Give with AM & PM meals. Initially 4mg twice daily; if well-tolerated, increase to maintenance dose 8mg twice daily (16mg/day) after minimum of 4 weeks; may attempt further increase to 12mg twice daily (24mg/day) after minimum of 4 weeks. Re-titrate if interrupted for >3 days. Moderate hepatic or renal impairment (CrCl 9–59mL/min): usual max 16mg/day.


Not established.

Galantamine Contraindications

Not Applicable

Galantamine Boxed Warnings

Not Applicable

Galantamine Warnings/Precautions


Discontinue at the first sign of skin rash, unless not drug-related; consider alternative therapy if serious skin reactions occur. Conduction disorders (eg, bradycardia, AV block). History of ulcer disease. Bladder outflow obstruction. Asthma. COPD. Seizures. Monitor for active or occult GI bleed, respiratory or neurological effects, and patient's weight. Maintain adequate hydration. Severe hepatic or renal impairment (CrCl <9mL/min): not recommended. Pregnancy. Nursing mothers.

Galantamine Pharmacokinetics

See Literature

Galantamine Interactions


Potentiates neuromuscular blockers (eg, succinylcholine), cholinesterase inhibitors, cholinergic agonists (eg, bethanechol). Antagonizes anticholinergics. Caution with drugs that slow heart rate. May be potentiated by ketoconazole, cimetidine, paroxetine, fluoxetine, erythromycin, possibly others that affect CYP2D6 or CYP3A4. Monitor for GI bleed with NSAIDs.

Galantamine Adverse Reactions

Adverse Reactions

Nausea, vomiting, diarrhea, dizziness, headache, decreased appetite, anorexia, weight loss, syncope, bradycardia, heart block, seizures; serious skin reactions (eg, Stevens-Johnson syndrome).

Galantamine Clinical Trials

See Literature

Galantamine Note


Formerly known under the brand name Razadyne.

Galantamine Patient Counseling

See Literature