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Furadantin Generic Name & Formulations
Legal Class
Rx
General Description
Nitrofurantoin 25mg/5mL; susp.
Pharmacological Class
Antibiotic.
How Supplied
Susp—230mL
Manufacturer
Generic Availability
YES
Furadantin Indications
Indications
Susceptible UTIs.
Furadantin Dosage and Administration
Adult
Take with food. 50–100mg 4 times daily. Suppressive therapy: 50–100mg once daily at bedtime may suffice.
Children
Take with food. <1month: contraindicated. ≥1month: 5–7mg/kg per day in 4 divided doses. Suppressive therapy: 1mg/kg per day in 1–2 divided doses may suffice.
Furadantin Contraindications
Contraindications
Renal impairment (CrCl <60mL/min or significantly elevated serum creatinine), anuria, oliguria. Neonates <1 month of age. Labor & delivery. Pregnancy at term. History of cholestatic jaundice or hepatic dysfunction.
Furadantin Boxed Warnings
Not Applicable
Furadantin Warnings/Precautions
Warnings/Precautions
Not for treating pyelonephritis or perinephric abscesses. Discontinue if pulmonary reactions, hepatitis, or hemolysis occurs. Monitor LFTs periodically. Renal insufficiency. G6PD or Vit. B deficiency. Anemia. Diabetes. Electrolyte imbalance. Debilitated. Monitor renal and pulmonary function in long-term use. Pregnancy. Nursing mothers: not recommended.
Furadantin Pharmacokinetics
See Literature
Furadantin Interactions
Interactions
Avoid magnesium trisilicate. Antagonized by, and increased toxicity with uricosurics (eg, probenecid, sulfinpyrazone). May cause false (+) glucose test with Benedict's or Fehling's solution.
Furadantin Adverse Reactions
Adverse Reactions
Nausea, emesis, anorexia, dizziness, headache, pulmonary reactions (esp. in long-term use), peripheral neuropathy, allergic reactions, C. difficile-associated diarrhea, hematologic disorders; rare: hepatic reactions, exfoliative dermatitis, Stevens-Johnson syndrome, optic neuritis, methemoglobinemia, aplastic anemia.
Furadantin Clinical Trials
See Literature
Furadantin Note
Not Applicable
Furadantin Patient Counseling
See Literature
