Migraine and headache:

Indications for: FROVA

Acute treatment of migraine.

Adult Dosage:

≥18yrs: 2.5mg with fluids; may repeat once after 2 hours; max 7.5mg/24 hours. Reevaluate if no response after 1st dose. The safety of treating an average of more than 4 headaches in a 30-day period has not been established.

Children Dosage:

<18yrs: not recommended.

FROVA Contraindications:

Ischemic cardiac, cerebro- or peripheral vascular disease (eg, history of MI, angina pectoris, silent myocardial ischemia, stroke, TIA, ischemic bowel disease). Uncontrolled hypertension. Wolff-Parkinson-White Syndrome or arrhythmias associated with other cardiac conduction pathway disorders. Basilar or hemiplegic migraine. Within 24 hours of other 5-HT1 agonists or ergot-type drugs.

FROVA Warnings/Precautions:

Confirm diagnosis. Exclude underlying cardiovascular disease, supervise 1st dose, consider monitoring ECG in patients with likelihood of unrecognized coronary disease (eg, postmenopausal women, men over age 40, hypertension, hypercholesterolemia, obesity, diabetes, smokers, strong family history). Monitor cardiovascular function in long-term intermittent use. Peripheral vascular or colonic ischemia after other 5-HT1 agonists. Severe hepatic impairment. Elderly. Pregnancy. Nursing mothers.

FROVA Classification:

Selective 5-HT1B/1D receptor agonist.

FROVA Interactions:

Methysergide, other ergotamines, or other 5-HT1 agonists: see Contraindications. Serotonin syndrome with SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline).

Adverse Reactions:

Dizziness, paresthesia, dry mouth, fatigue, flushing, hot or cold sensation, dyspepsia, skeletal pain, chest/throat/neck symptoms (pain, pressure, tightness); serious cardiac events (rare).

Generic Drug Availability:


How Supplied:

Tabs—9, 100