Fosinopril Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Fosinopril Indications
Indications
Fosinopril Dosage and Administration
Adult
Children
Renal Impairment
-
In patients with severe CHF whose renal function may depend on the renin-angiotensin-aldosterone system, treatment with ACE inhibitors, including fosinopril sodium, may be associated with oliguria and/or progressive azotemia and (rarely) with acute renal failure and/or death.
-
In hypertensive patients with renal artery stenosis in a solitary kidney or bilateral renal artery stenosis, increases in BUN and serum creatinine may occur. In these patients, monitor renal function during the first few weeks of therapy.
Hepatic Impairment
-
Discontinue ACE inhibitor if patients develop jaundice or marked elevations of hepatic enzymes and administer appropriate medical follow-up.
Fosinopril Contraindications
Contraindications
Hypersensitivity to fosinopril or any other ACE inhibitor (eg, angioedema). Concomitant use with aliskiren in patients with diabetes.
Fosinopril Boxed Warnings
Not Applicable
Fosinopril Warnings/Precautions
Warnings/Precautions
Fosinopril Pharmacokinetics
Absorption
Following oral administration, fosinopril (the prodrug) is absorbed slowly. The absolute absorption of fosinopril averaged 36% of an oral dose. The primary site of absorption is the proximal small intestine (duodenum/jejunum). While the rate of absorption may be slowed by the presence of food in the gastrointestinal tract, the extent of absorption of fosinopril is essentially unaffected.
Distribution
Fosinoprilat is highly protein-bound (approximately 99.4%), has a relatively small volume of distribution, and has negligible binding to cellular components in blood. After single and multiple oral doses, plasma levels, areas under plasma concentration-time curves (AUCs) and peak concentrations (Cmaxs) are directly proportional to the dose of fosinopril. Times to peak concentrations are independent of dose and are achieved in approximately 3 hours.
Elimination
After oral administration of radiolabeled fosinopril, approximately half of the absorbed dose is excreted in the urine and the remainder is excreted in the feces. In hypertensive patients with normal renal and hepatic function, who received repeated doses of fosinopril, the effective half-life for accumulation of fosinoprilat averaged 11.5 hours. In patients with heart failure, the effective half-life was 14 hours.
Fosinopril Interactions
Interactions
Fosinopril Adverse Reactions
Adverse Reactions
Fosinopril Clinical Trials
Fosinopril Note
Notes
Fosinopril Patient Counseling
Fosinopril Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Fosinopril Indications
Indications
Fosinopril Dosage and Administration
Adult
Children
Renal Impairment
-
In patients with severe CHF whose renal function may depend on the renin-angiotensin-aldosterone system, treatment with ACE inhibitors, including fosinopril sodium, may be associated with oliguria and/or progressive azotemia and (rarely) with acute renal failure and/or death.
-
In hypertensive patients with renal artery stenosis in a solitary kidney or bilateral renal artery stenosis, increases in BUN and serum creatinine may occur. In these patients, monitor renal function during the first few weeks of therapy.
Hepatic Impairment
-
Discontinue ACE inhibitor if patients develop jaundice or marked elevations of hepatic enzymes and administer appropriate medical follow-up.
Fosinopril Contraindications
Contraindications
Hypersensitivity to fosinopril or any other ACE inhibitor (eg, angioedema). Concomitant use with aliskiren in patients with diabetes.
Fosinopril Boxed Warnings
Not Applicable
Fosinopril Warnings/Precautions
Warnings/Precautions
Fosinopril Pharmacokinetics
Absorption
Following oral administration, fosinopril (the prodrug) is absorbed slowly. The absolute absorption of fosinopril averaged 36% of an oral dose. The primary site of absorption is the proximal small intestine (duodenum/jejunum). While the rate of absorption may be slowed by the presence of food in the gastrointestinal tract, the extent of absorption of fosinopril is essentially unaffected.
Distribution
Fosinoprilat is highly protein-bound (approximately 99.4%), has a relatively small volume of distribution, and has negligible binding to cellular components in blood. After single and multiple oral doses, plasma levels, areas under plasma concentration-time curves (AUCs) and peak concentrations (Cmaxs) are directly proportional to the dose of fosinopril. Times to peak concentrations are independent of dose and are achieved in approximately 3 hours.
Elimination
After oral administration of radiolabeled fosinopril, approximately half of the absorbed dose is excreted in the urine and the remainder is excreted in the feces. In hypertensive patients with normal renal and hepatic function, who received repeated doses of fosinopril, the effective half-life for accumulation of fosinoprilat averaged 11.5 hours. In patients with heart failure, the effective half-life was 14 hours.