• Hypertension

Fosinopril/hydrochlorothiazide Generic Name & Formulations

General Description

Fosinopril sodium, hydrochlorothiazide; 10mg/12.5mg, 20mg/12.5mg; tabs.

Pharmacological Class

ACE inhibitor + diuretic (thiazide).

How Supplied

Contact supplier.

Fosinopril/hydrochlorothiazide Indications


Hypertension. Not for initial therapy.

Fosinopril/hydrochlorothiazide Dosage and Administration


Give once daily. Usual range: fosinopril: 10–20mg; HCTZ: 12.5–50mg. Severe renal impairment (CrCl<30mL/min): not recommended.


Not recommended.

Fosinopril/hydrochlorothiazide Contraindications


Anuria. Hypersensitivity to ACE inhibitors, sulfonamide-derived drugs.

Fosinopril/hydrochlorothiazide Boxed Warnings

Not Applicable

Fosinopril/hydrochlorothiazide Warnings/Precautions


Discontinue if angioedema, laryngeal edema, jaundice, or markedly elevated liver enzymes occurs. Salt/volume depletion; correct before initiating therapy. Renal or hepatic impairment. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Surgery. Diabetes. Gout. SLE. Monitor WBCs in renal or collagen vascular disease. Monitor electrolytes, BUN (if high). Pregnancy (Cat.C in 1st trimester; Cat.D in 2nd and 3rd trimester). Nursing mothers: not recommended.

Fosinopril/hydrochlorothiazide Pharmacokinetics

See Literature

Fosinopril/hydrochlorothiazide Interactions


Potassium or K+-sparing diuretics may cause hyperkalemia. May increase lithium levels. Antagonized by NSAIDs. Separate antacid dosing by 2hrs. May cause false low serum digoxin measurements. May antagonize norepinephrine, methenamine. May potentiate nondepolarizing muscle relaxants. Adjust antidiabetic, antigout medications. ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid tests. Nitritoid reactions with injectable gold.

Fosinopril/hydrochlorothiazide Adverse Reactions

Adverse Reactions

Headache, cough, fatigue; hyperkalemia, orthostatic hypotension, angioedema (discontinue if occurs).

Fosinopril/hydrochlorothiazide Clinical Trials

See Literature

Fosinopril/hydrochlorothiazide Note


Formerly known under the brand name Monopril HCT.

Fosinopril/hydrochlorothiazide Patient Counseling

See Literature