Fomepizole Generic Name & Formulations
Fomepizole 1g/mL; soln for IV infusion after dilution; preservative-free.
Alcohol dehydrogenase inhibitor.
Ethylene glycol or methanol poisoning; or suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis.
Fomepizole Dosage and Administration
Give by slow IV infusion over 30mins. Loading dose of 15mg/kg, followed by 10mg/kg every 12hrs for 4 doses, then 15mg/kg every 12hrs until ethylene glycol or methanol concentration is <20mg/dL and patient is asymptomatic with normal pH. Hemodialysis: see full labeling.
Allergy to pyrazoles.
Fomepizole Boxed Warnings
For dilution/administration: do not use polycarbonate syringes or polycarbonate-containing needles. Renal or hepatic impairment. Renal failure, significant or worsening metabolic acidosis, or high ethylene glycol or methanol concentrations (≥50mg/dL); consider hemodialysis in addition to fomepizole. Obtain blood gases, pH, electrolytes, liver enzymes, BUN, creatinine, urinalysis, ECG, WBCs frequently during therapy. Monitor serum and urine ethylene glycol concentrations and presence of urinary oxalate crystals; or serum methanol concentrations. Monitor for allergic reactions. Elderly. Pregnancy (Cat.C). Nursing mothers.
Potentiates or potentiated by ethanol. May affect or be affected by CYP450 inducers/inhibitors (eg, phenytoin, carbamazepine, cimetidine, ketoconazole).
Fomepizole Adverse Reactions
Headache, nausea, dizziness, drowsiness, bad taste/metallic taste; rare: mild rash, eosinophilia.
Fomepizole Clinical Trials
Fomepizole Patient Counseling