• Poisoning/overdose

Fomepizole Generic Name & Formulations

General Description

Fomepizole 1g/mL; soln for IV infusion after dilution; preservative-free.

Pharmacological Class

Alcohol dehydrogenase inhibitor.

How Supplied

Contact supplier

Fomepizole Indications


Ethylene glycol or methanol poisoning; or suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis.

Fomepizole Dosage and Administration


Give by slow IV infusion over 30mins. Loading dose of 15mg/kg, followed by 10mg/kg every 12hrs for 4 doses, then 15mg/kg every 12hrs until ethylene glycol or methanol concentration is <20mg/dL and patient is asymptomatic with normal pH. Hemodialysis: see full labeling.


Not established.

Fomepizole Contraindications


Allergy to pyrazoles.

Fomepizole Boxed Warnings

Not Applicable

Fomepizole Warnings/Precautions


For dilution/administration: do not use polycarbonate syringes or polycarbonate-containing needles. Renal or hepatic impairment. Renal failure, significant or worsening metabolic acidosis, or high ethylene glycol or methanol concentrations (≥50mg/dL); consider hemodialysis in addition to fomepizole. Obtain blood gases, pH, electrolytes, liver enzymes, BUN, creatinine, urinalysis, ECG, WBCs frequently during therapy. Monitor serum and urine ethylene glycol concentrations and presence of urinary oxalate crystals; or serum methanol concentrations. Monitor for allergic reactions. Elderly. Pregnancy (Cat.C). Nursing mothers.

Fomepizole Pharmacokinetics

See Literature

Fomepizole Interactions


Potentiates or potentiated by ethanol. May affect or be affected by CYP450 inducers/inhibitors (eg, phenytoin, carbamazepine, cimetidine, ketoconazole).

Fomepizole Adverse Reactions

Adverse Reactions

Headache, nausea, dizziness, drowsiness, bad taste/metallic taste; rare: mild rash, eosinophilia.

Fomepizole Clinical Trials

See Literature

Fomepizole Note

Not Applicable

Fomepizole Patient Counseling

See Literature