Flutamide Generic Name & Formulations
Flutamide 125mg; caps.
In combination with LHRH agonists (GnRH analogues) in locally confined stage B2–C and stage D2 metastatic prostate carcinoma.
Flutamide Dosage and Administration
250mg every 8 hrs.
Severe hepatic impairment. ALT ≥2xULN: not recommended.
Flutamide Boxed Warnings
Monitor liver function at baseline, monthly for first 4 months, then periodically, and if liver dysfunction occurs; if ALT >2xULN or jaundice occurs, discontinue and monitor closely until resolution. Monitor prostate specific antigen (PSA). Consider monitoring methemoglobin levels in patients susceptible to aniline toxicity (e.g., G6PD deficiency, smokers, hemoglobin M disease). Pregnancy (Cat.D); not for use in women.
Flutamide Adverse Reactions
Diarrhea, hot flashes, loss of libido, impotence, GI disturbances, gynecomastia, rash, edema, hypertension, CNS effects, blood dyscrasias, urine discoloration, liver failure.
Flutamide Clinical Trials
Formerly known under the brand name Eulexin.
Flutamide Patient Counseling