Flurbiprofen Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Flurbiprofen Indications
Indications
Flurbiprofen Dosage and Administration
Adult
Children
Renal Impairment
Monitor patients with significantly impaired renal function closely.
Not recommended in patients with advanced renal disease; if needed, close monitoring of the patient’s renal function is advisable.
Hepatic Impairment
Patients with hepatic disease may require reduced doses of flurbiprofen as hepatic metabolism accounts for >90% of flurbiprofen elimination.
Other Modifications
NSAIDs may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women.
Consider withdrawing flurbiprofen in women who have difficulties conceiving or who are undergoing investigation of infertility.
Flurbiprofen Contraindications
Contraindications
Flurbiprofen Boxed Warnings
Boxed Warning
Flurbiprofen Warnings/Precautions
Warnings/Precautions
Flurbiprofen Pharmacokinetics
Absorption
Peak plasma concentrations occur at approximately 2 hours; administration of food or antacids may alter the rate of absorption.
Distribution
99% bound to plasma proteins.
Elimination
Predominantly renal elimination. Half-life of R- and S-flurbiprofen are similar, about 4.7 and 5.7 hours, respectively.
Flurbiprofen Interactions
Interactions
Flurbiprofen Adverse Reactions
Adverse Reactions
Flurbiprofen Clinical Trials
See Literature