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Fluorouracil Generic Name & Formulations
Legal Class
Rx
General Description
Fluorouracil 50mg/mL; soln for IV inj.
Pharmacological Class
Antimetabolite.
How Supplied
Contact supplier.
Manufacturer
Fluorouracil Indications
Indications
Palliative management of carcinoma of the breast.
Fluorouracil Dosage and Administration
Adult
Give by IV inj. 12mg/kg once daily for 4 successive days; max 800mg/day. If no toxicity is observed, 6mg/kg are given on the 6th, 8th, 10th, and 12th days unless toxicity occurs. Maintenance therapy: repeat dosage of 1st course every 30 days after the last day of the previous course of treatment; or give a maintenance dose of 10–15mg/kg per week as a single dose; max: 1g/week. Poor risk patients: see literature for dose adjustments.
Children
Not recommended.
Fluorouracil Contraindications
Contraindications
Poor nutritional state. Depressed bone marrow function. Potentially serious infections.
Fluorouracil Boxed Warnings
Not Applicable
Fluorouracil Warnings/Precautions
Warnings/Precautions
Narrow margin of safety; monitor for toxicity. Consider hospitalization for 1st course. History of high-dose pelvic irradiation. Previous use of alkylating agents. Widespread involvement of bone marrow by metastatic tumors. Renal or hepatic impairment. Discontinue if signs of toxicity appear (eg, stomatitis, esophagopharyngitis, leukopenia, intractable vomiting, diarrhea, GI ulceration or bleeding, thrombocytopenia, hemorrhage). Monitor WBCs with differential before each dose. Avoid extravasation. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Fluorouracil Pharmacokinetics
See Literature
Fluorouracil Interactions
Interactions
Potentiated by leucovorin.
Fluorouracil Adverse Reactions
Adverse Reactions
Stomatitis, esophagopharyngitis, GI upset, anorexia, leukopenia, alopecia, dermatitis, hand-foot syndrome; others.
Fluorouracil Clinical Trials
See Literature
Fluorouracil Note
Notes
Testing considerations: TS (thymidylate synthase), MSI (microsatellite instability), DPD (dihydropyrimidine dehydrogenase). Formerly known under the brand name Adrucil.
Fluorouracil Patient Counseling
See Literature
Fluorouracil Generic Name & Formulations
Legal Class
Rx
General Description
Fluorouracil 50mg/mL; soln for IV inj.
Pharmacological Class
Antimetabolite.
How Supplied
Contact supplier.
Manufacturer
Fluorouracil Indications
Indications
Palliative management of carcinoma of the colon, rectum, and stomach.
Fluorouracil Dosage and Administration
Adult
Give by IV inj. 12mg/kg once daily for 4 successive days; max 800mg/day. If no toxicity is observed, 6mg/kg are given on the 6th, 8th, 10th, and 12th days unless toxicity occurs. Maintenance therapy: repeat dosage of 1st course every 30 days after the last day of the previous course of treatment; or give a maintenance dose of 10–15mg/kg per week as a single dose; max: 1g/week. Poor risk patients: see literature for dose adjustments.
Children
Not recommended.
Fluorouracil Contraindications
Contraindications
Poor nutritional state. Depressed bone marrow function. Potentially serious infections.
Fluorouracil Boxed Warnings
Not Applicable
Fluorouracil Warnings/Precautions
Warnings/Precautions
Narrow margin of safety; monitor for toxicity. Consider hospitalization for 1st course. History of high-dose pelvic irradiation. Previous use of alkylating agents. Widespread involvement of bone marrow by metastatic tumors. Renal or hepatic impairment. Discontinue if signs of toxicity appear (eg, stomatitis, esophagopharyngitis, leukopenia, intractable vomiting, diarrhea, GI ulceration or bleeding, thrombocytopenia, hemorrhage). Monitor WBCs with differential before each dose. Avoid extravasation. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Fluorouracil Pharmacokinetics
See Literature
Fluorouracil Interactions
Interactions
Potentiated by leucovorin.
Fluorouracil Adverse Reactions
Adverse Reactions
Stomatitis, esophagopharyngitis, GI upset, anorexia, leukopenia, alopecia, dermatitis, hand-foot syndrome; others.
Fluorouracil Clinical Trials
See Literature
Fluorouracil Note
Notes
Testing considerations: TS (thymidylate synthase), MSI (microsatellite instability), DPD (dihydropyrimidine dehydrogenase). Formerly known under the brand name Adrucil.
Fluorouracil Patient Counseling
See Literature
Fluorouracil Generic Name & Formulations
Legal Class
Rx
General Description
Fluorouracil 50mg/mL; soln for IV inj.
Pharmacological Class
Antimetabolite.
How Supplied
Contact supplier.
Manufacturer
Fluorouracil Indications
Indications
Palliative management of carcinoma of the pancreas.
Fluorouracil Dosage and Administration
Adult
Give by IV inj. 12mg/kg once daily for 4 successive days; max 800mg/day. If no toxicity is observed, 6mg/kg are given on the 6th, 8th, 10th, and 12th days unless toxicity occurs. Maintenance therapy: repeat dosage of 1st course every 30 days after the last day of the previous course of treatment; or give a maintenance dose of 10–15mg/kg per week as a single dose; max: 1g/week. Poor risk patients: see literature for dose adjustments.
Children
Not recommended.
Fluorouracil Contraindications
Contraindications
Poor nutritional state. Depressed bone marrow function. Potentially serious infections.
Fluorouracil Boxed Warnings
Not Applicable
Fluorouracil Warnings/Precautions
Warnings/Precautions
Narrow margin of safety; monitor for toxicity. Consider hospitalization for 1st course. History of high-dose pelvic irradiation. Previous use of alkylating agents. Widespread involvement of bone marrow by metastatic tumors. Renal or hepatic impairment. Discontinue if signs of toxicity appear (eg, stomatitis, esophagopharyngitis, leukopenia, intractable vomiting, diarrhea, GI ulceration or bleeding, thrombocytopenia, hemorrhage). Monitor WBCs with differential before each dose. Avoid extravasation. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Fluorouracil Pharmacokinetics
See Literature
Fluorouracil Interactions
Interactions
Potentiated by leucovorin.
Fluorouracil Adverse Reactions
Adverse Reactions
Stomatitis, esophagopharyngitis, GI upset, anorexia, leukopenia, alopecia, dermatitis, hand-foot syndrome; others.
Fluorouracil Clinical Trials
See Literature
Fluorouracil Note
Notes
Testing considerations: TS (thymidylate synthase), MSI (microsatellite instability), DPD (dihydropyrimidine dehydrogenase). Formerly known under the brand name Adrucil.
Fluorouracil Patient Counseling
See Literature
