• Poisoning/overdose

Flumazenil Generic Name & Formulations

General Description

Flumazenil 0.1mg/mL; IV inj.

Pharmacological Class

Benzodiazepine antagonist.

How Supplied

Contact supplier.

Flumazenil Indications


Reversal of benzodiazepine sedative effects in overdose, general anesthesia or conscious sedation.

Flumazenil Dosage and Administration


Overdose: Give dose over 30 seconds by IV infusion. Initially: 0.2mg. After 30 seconds (if needed), 0.3mg. Then 0.5mg at 60 second intervals up to 3mg cumulative dose. Usual range: 1–3mg. If partial response occurs at 3mg cumulative dose, may titrate up to 5mg cumulative dose. Conscious sedation, general anesthesia, resedation: see full labeling.


<1yr: not recommended. 1–17yrs: for reversal of benzodiazepine-induced conscious sedation only. See full labeling.

Flumazenil Contraindications


Patients treated with benzodiazepines for life threatening conditions. Mixed overdose patients when seizures likely (esp. cyclic antidepressants).

Flumazenil Boxed Warnings

Boxed Warning

Occurrence of seizures.

Flumazenil Warnings/Precautions


Monitor for resedation (at least 2hrs), respiratory depression, other residual benzodiazepine effects, seizures. Seizure disorders or risk. Drug or alcohol dependence. Head injury. Panic disorder. Hepatic disease. Counsel on post-procedure period (see full labeling). Labor & delivery: not recommended. Pregnancy (Cat.C). Nursing mothers.

Flumazenil Pharmacokinetics

See Literature

Flumazenil Interactions


Avoid use until neuromuscular blockade reversed. Avoid alcohol, sedatives for 18–24hrs after treatment. Potentiates toxicity of cyclic antidepressant or mixed drug overdose.

Flumazenil Adverse Reactions

Adverse Reactions

Seizures, local reactions, dizziness, increased sweating, headache, blurred vision, GI upset, agitation, benzodiazepine withdrawal syndrome.

Flumazenil Clinical Trials

See Literature

Flumazenil Note

Not Applicable

Flumazenil Patient Counseling

See Literature