• Colorectal and other GI cancers

Floxuridine Generic Name & Formulations

General Description

Floxuridine 500mg/vial; lyophilized pwd for intra-arterial infusion after reconstitution and dilution.

Pharmacological Class


How Supplied

Contact supplier.

Floxuridine Indications


Palliative therapy of GI adenocarcinoma with liver metastases in select patients (see literature).

Floxuridine Dosage and Administration


Continuous arterial infusion 0.1–0.6mg/kg per day. Hepatic artery infusion: 0.4–0.6mg/kg per day. May give until adverse reactions occur; treat as long as response continues. See literature.


Not recommended.

Floxuridine Contraindications


Poor nutritional state. Myelosuppression. Serious infections.

Floxuridine Boxed Warnings

Not Applicable

Floxuridine Warnings/Precautions


Hospitalize for 1st course. Hepatic or renal dysfunction. History of high-dose pelvic irradiation or alkylation therapy. Monitor blood (esp WBC, platelets). Discontinue for myocardial ischemia, stomatitis or esophagopharyngitis, WBC <3500 or rapidly falling, intractable vomiting, GI ulcer/bleeding, diarrhea, platelets <100000, hemorrhage. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Floxuridine Pharmacokinetics

See Literature

Floxuridine Interactions

Floxuridine Adverse Reactions

Adverse Reactions

GI upset, enteritis, stomatitis, localized erythema, myelosuppression, liver dysfunction, GI bleeding/ulcer, duodenitis, gastroenteritis, glossitis, pharyngitis, intra- and extrahepatic biliary sclerosis, acalculous cholecystitis, alopecia, dermatitis, myocardial ischemia, fever, malaise; lab abnormalities (eg, anemia, leukopenia, thrombocytopenia, abnormal PT, total proteins, ESR, ALT/SGOT, bilirubin, lactic dehydrogenase); procedural complications (eg, arterial aneurysm, ischemia, thrombotic events, fibromyositis, thrombophlebitis, hepatic necrosis, abscess).

Floxuridine Clinical Trials

See Literature

Floxuridine Note


Formerly known under the brand name FUDR.

Floxuridine Patient Counseling

See Literature