• Seizure disorders

Felbatol Generic Name & Formulations

General Description

Felbamate 400mg, 600mg; scored tabs.

Pharmacological Class


How Supplied

Tabs—100; Susp—4oz, 8oz, 32oz


Generic Availability


Felbatol Indications


Not a first-line treatment. Partial seizures with or without generalization in adults. Adjunct in Lennox-Gastaut syndrome in children.

Felbatol Dosage and Administration


See full labeling. ≥14yrs: initial monotherapy: 1.2g/day in 3–4 divided doses, increase by 600mg every 2 weeks to 2.4g/day and up to 3.6g/day if needed. Conversion to monotherapy/adjunctive therapy: 1.2g/day in 3–4 divided doses, increase to 2.4g/day at week 2, and to 3.6g/day at week 3. Dosages of concomitant anticonvulsant drugs should be reduced upon the initiation of felbamate therapy and weekly thereafter (see full labeling). Renal dysfunction: reduce initial and maintenance dose by ½.


Lennox-Gastaut: ≥2yrs: 15mg/kg per day in 3–4 divided doses, increase dose by 15mg/kg per day at 1 week intervals to 45mg/kg per day. Dose of concomitant anticonvulsant drug should be reduced upon the initiation of felbamate therapy (see full labeling).

Felbatol Contraindications


History of hepatic dysfunction or blood dyscrasias.

Felbatol Boxed Warnings

Boxed Warning

Aplastic anemia. Hepatic failure.

Felbatol Warnings/Precautions


Increased risk of aplastic anemia or hepatic failure. Do full baseline hematologic evaluations and hepatic function tests before, during, and after therapy; discontinue if hepatic tests are abnormal or bone marrow depression occurs; consult hematologist if hematological abnormalities occur. Suicidal tendencies (monitor). Adjust dose of and monitor other anticonvulsants. Avoid abrupt cessation. Obtain written informed consent. Pregnancy (Cat.C). Nursing mothers.

Felbatol Pharmacokinetics

See Literature

Felbatol Interactions


Increases serum levels of phenytoin, valproate, carbamazepine metabolite. Decreases carbamazepine levels. Serum levels decreased by phenytoin, carbamazepine.

Felbatol Adverse Reactions

Adverse Reactions

Anorexia, vomiting, insomnia, nausea, headache; rare: primary hepatotoxicity, aplastic anemia.

Felbatol Clinical Trials

See Literature

Felbatol Note

Not Applicable

Felbatol Patient Counseling

See Literature