• Viral infections

Famciclovir Generic Name & Formulations

General Description

Famciclovir (prodrug of penciclovir) 125mg, 250mg, 500mg; tabs.

Pharmacological Class

Nucleoside analogue.

How Supplied

Contact supplier.

Famciclovir Indications


In immunocompetent adults: treatment of recurrent herpes labialis, treatment of recurrent episodes of genital herpes, chronic suppressive therapy of recurrent episodes of genital herpes, treatment of herpes zoster. In HIV-infected adults: treatment of recurrent episodes of orolabial or genital herpes. Limitations of use: not established for patients with 1st episode of genital herpes or ophthalmic zoster, immunocompromised patients other than for treatment of recurrent orolabial or genital herpes in HIV-infected patients, Black and African American patients with recurrent genital herpes.

Famciclovir Dosage and Administration


≥18yrs: Herpes zoster: start as soon as herpes zoster is diagnosed (within 72hrs of onset of rash); treat for 7 days; 500mg every 8hrs. CrCl 40–59mL/min: 500mg every 12hrs; CrCl 20–39mL/min: 500mg every 24hrs; CrCl <20mL/min: 250mg every 24hrs; hemodialysis (HD): 250mg after each dialysis. Treatment of recurrent genital herpes: begin therapy at first sign or symptom (within 6hrs); 1000mg every 12hrs for 1 day; CrCl 40–59mL/min: 500mg every 12hrs for 1 day; CrCl 20–39mL/min: 500mg single dose; CrCl <20mL/min: 250mg single dose; HD: 250mg after dialysis. Suppression of recurrent genital herpes: 250mg every 12hrs (for up to 1yr). CrCl 20–39mL/min: 125mg every 12hrs; CrCl <20mL/min: 125mg every 24hrs; HD: 125mg after each dialysis. Recurrent herpes labialis: start at first sign or symptom of cold sore: treat with single dose: 1500mg. CrCl 40–59mL/min: 750mg; CrCl 20–39mL/min: 500mg; CrCl <20mL/min: 250mg; HD: 250mg following dialysis. Orolabial or genital herpes simplex in HIV patients: treat for 7 days: 500mg every 12hrs; CrCl 20–39mL/min: 500mg every 24hrs; CrCl <20mL/min: 250mg every 24hrs; HD: 250mg after each dialysis.


<18yrs: not established.

Famciclovir Contraindications


Allergic to penciclovir cream.

Famciclovir Boxed Warnings

Not Applicable

Famciclovir Warnings/Precautions


Renal dysfunction. Pregnancy. Nursing mothers.

Famciclovir Pharmacokinetics

See Literature

Famciclovir Interactions


Probenecid, others eliminated by active tubular secretion may increase penciclovir concentrations. May be affected by drugs metabolized by aldehyde oxidase.

Famciclovir Adverse Reactions

Adverse Reactions

Headache, nausea, fatigue, paresthesia, pruritus.

Famciclovir Clinical Trials

See Literature

Famciclovir Note


Formerly known under the brand name Famvir.

Famciclovir Patient Counseling

See Literature