• Multiple sclerosis

Extavia Generic Name & Formulations

General Description

Interferon beta-1b 0.3mg/vial; lyophilized pwd for SC inj after reconstitution; preservative-free; contains albumin (human), mannitol.

Pharmacological Class


How Supplied

Single-use vials—15 (w. prefilled diluent syringe, supplies)

Generic Availability


Mechanism of Action

The mechanism of action of interferon beta-1b in patients with MS is unknown.

Extavia Indications


Relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.

Extavia Dosage and Administration


Pre-medicate with analgesics and/or antipyretics on treatment days to ameliorate flu-like symptoms. Rotate inj sites. ≥18yrs: initially 0.0625mg SC every other day; increase by 25% every 2 weeks to target dose of 0.25mg SC every other day.


<18yrs: not established.

Extavia Contraindications

Not Applicable

Extavia Boxed Warnings

Not Applicable

Extavia Warnings/Precautions


Monitor for hepatic injury; consider discontinuing if elevated transaminase levels or jaundice occurs. Depression. Suicidal ideation. Pre-existing CHF: monitor for worsening cardiac function at initiation and during treatment. Discontinue if thrombotic microangiopathy or signs/symptoms of drug-induced lupus erythematosus occurs. Myelosuppression. Monitor CBCs, differential, platelets, chemistries, liver function tests (at 1, 3, and 6 months then periodically). Risk for pulmonary arterial hypertension (PAH); evaluate and discontinue if PAH is confirmed. Latex allergy (diluent). Pregnancy. Nursing mothers.

Extavia Pharmacokinetics

See Literature

Extavia Interactions


Risk of hepatic injury with concomitant hepatotoxic drugs or other products (eg, alcohol).

Extavia Adverse Reactions

Adverse Reactions

Inj site reactions (necrosis, cellulitis, abscess, inflammation, pain), lymphopenia, flu-like symptoms, myalgia, leukopenia, neutropenia, increased liver enzymes, headache, hypertonia, rash, insomnia, abdominal pain, asthenia; rare: hepatic injury, anaphylaxis (discontinue if occurs), possible seizures.

Extavia Clinical Trials

See Literature

Extavia Note

Not Applicable

Extavia Patient Counseling

See Literature