• Miscellaneous neurodegenerative disorders

Exservan Generic Name & Formulations

General Description

Riluzole 50mg; oral films.

Pharmacological Class


How Supplied

Oral films—60

Generic Availability


Exservan Indications


Amyotrophic lateral sclerosis (ALS).

Exservan Dosage and Administration


Take ≥1hr before or 2hrs after a meal. Dissolve on tongue and swallow. 50mg twice daily.


Not established.

Exservan Contraindications

Not Applicable

Exservan Boxed Warnings

Not Applicable

Exservan Warnings/Precautions


Monitor for hepatic injury monthly for the first 3 months, and periodically thereafter. Measure serum aminotransferases before and during treatment. If ALT >5×ULN: not recommended. Discontinue if liver dysfunction evident (eg, elevated bilirubin). Risk of neutropenia: monitor for febrile illness. Discontinue immediately if interstitial lung disease develops. Japanese patients (higher drug concentration/adverse reactions). Hepatic impairment. Elderly. Pregnancy. Nursing mothers.

Exservan Pharmacokinetics

See Literature

Exservan Interactions


May be potentiated by strong or moderate CYP1A2 inhibitors (eg, ciprofloxacin, enoxacin, fluvoxamine, methoxsalen, mexiletine, oral contraceptives, thiabendazole, vemurafenib, zileuton). May be antagonized by CYP1A2 inducers. Increased risk of hepatotoxicity with concomitant other hepatotoxic agents (eg, allopurinol, methyldopa, sulfasalazine).

Exservan Adverse Reactions

Adverse Reactions

Oral hypoesthesia, asthenia, nausea, decreased lung function, hypertension, abdominal pain; elevated ALTs, severe neutropenia, interstitial lung disease, hypersensitivity pneumonitis.

Exservan Clinical Trials

See Literature

Exservan Note

Not Applicable

Exservan Patient Counseling

See Literature