Miscellaneous neurodegenerative disorders:

Indications for: EXSERVAN

Amyotrophic lateral sclerosis (ALS).

Adult Dosage:

Take ≥1hr before or 2hrs after a meal. Dissolve on tongue and swallow. 50mg twice daily.

Children Dosage:

Not established.

EXSERVAN Warnings/Precautions:

Monitor for hepatic injury monthly for the first 3 months, and periodically thereafter. Measure serum aminotransferases before and during treatment. If ALT >5×ULN: not recommended. Discontinue if liver dysfunction evident (eg, elevated bilirubin). Risk of neutropenia: monitor for febrile illness. Discontinue immediately if interstitial lung disease develops. Japanese patients (higher drug concentration/adverse reactions). Hepatic impairment. Elderly. Pregnancy. Nursing mothers.

EXSERVAN Classification:

Benzothiazole.

EXSERVAN Interactions:

May be potentiated by strong or moderate CYP1A2 inhibitors (eg, ciprofloxacin, enoxacin, fluvoxamine, methoxsalen, mexiletine, oral contraceptives, thiabendazole, vemurafenib, zileuton). May be antagonized by CYP1A2 inducers. Increased risk of hepatotoxicity with concomitant other hepatotoxic agents (eg, allopurinol, methyldopa, sulfasalazine).

Adverse Reactions:

Oral hypoesthesia, asthenia, nausea, decreased lung function, hypertension, abdominal pain; elevated ALTs, severe neutropenia, interstitial lung disease, hypersensitivity pneumonitis.

Generic Drug Availability:

NO

How Supplied:

Oral films—60

Pricing for EXSERVAN

60 pouches of 50mg carton (Qty: 1)
Appx. price $3216
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