Exondys 51

  • Miscellaneous musculoskeletal disorders

Exondys 51 Generic Name & Formulations

General Description

Eteplirsen 50mg/mL; per vial; soln for IV infusion after dilution; preservative-free.

Pharmacological Class

Antisense oligonucleotide.

How Supplied

Single-dose vial (2mL, 10mL)—1


Generic Availability


Exondys 51 Indications


Duchenne muscular dystrophy (DMD) in patients with a confirmed DMD gene mutation that is amenable to exon 51 skipping.

Exondys 51 Dosage and Administration

Adults and Children

May apply topical anesthetic cream to IV site prior to administration. Give by IV infusion over 35–60mins. 30mg/kg once weekly.

Exondys 51 Contraindications

Not Applicable

Exondys 51 Boxed Warnings

Not Applicable

Exondys 51 Warnings/Precautions


Treat appropriately and consider slowing the infusion or interrupting therapy if hypersensitivity reactions occur. Renal impairment. Pregnancy. Nursing mothers.

Exondys 51 Pharmacokinetics

See Literature

Exondys 51 Interactions


Do not mix or infuse with other medications concomitantly via same IV access line.

Exondys 51 Adverse Reactions

Adverse Reactions

Balance disorder, vomiting, contact dermatitis; hypersensitivity reactions.

Exondys 51 Clinical Trials

See Literature

Exondys 51 Note

Not Applicable

Exondys 51 Patient Counseling

See Literature