Excedrin Migraine

  • Migraine and headache

Excedrin Migraine Generic Name & Formulations

General Description

Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; coated caplets.

Pharmacological Class

Analgesic + salicylate.

How Supplied

Caplets—24, 100, 200

Excedrin Migraine Indications



Excedrin Migraine Dosage and Administration


≥18yrs: 2 caplets with a glass of water; max 2 caplets/24hrs.


<18yrs: consult physician.

Excedrin Migraine Contraindications


NSAID allergy. Varicella, vaccinia in children and teenagers.

Excedrin Migraine Boxed Warnings

Not Applicable

Excedrin Migraine Warnings/Precautions


Reye's syndrome. Persistent or unresponsive headache. Hypertension. Cardiovascular disease. Asthma. Peptic ulcer. GI bleeding disorders. Liver cirrhosis. Hepatic or renal impairment. Discontinue if signs/symptoms of GI bleed, migraine is not relieved or worsens after first dose, tinnitus, loss of hearing, new or unexpected symptoms develop, or severe skin reactions (eg, skin reddening, blisters, rash) occur. Headaches may worsen if used for ≥10 days per month. Elderly (≥60yrs). Pregnancy (esp. during ≥20 weeks): not recommended. Nursing mothers.

Excedrin Migraine Pharmacokinetics

See Literature

Excedrin Migraine Interactions


May potentiate anticoagulants, hypoglycemics, methotrexate. May antagonize uricosurics. Increased risk of liver toxicity and/or GI bleed with ≥3 alcoholic drinks/day or concomitant other drugs containing acetaminophen, NSAIDs. Caution with diuretics, corticosteroids.

Excedrin Migraine Adverse Reactions

Adverse Reactions

GI upset/bleed, prolonged bleeding time, urticaria, anaphylaxis; overdosage: salicylism, hepatoxicity.

Excedrin Migraine Clinical Trials

See Literature

Excedrin Migraine Note

Not Applicable

Excedrin Migraine Patient Counseling

See Literature