Excedrin Extra Strength

  • Nonnarcotic analgesics

Excedrin Extra Strength Generic Name & Formulations

General Description

Acetaminophen 250mg, aspirin 250mg, caffeine 65mg; caplets.

Pharmacological Class

Analgesic + salicylate.

How Supplied

Caplets—24, 200

Excedrin Extra Strength Indications


Minor aches and pains.

Excedrin Extra Strength Dosage and Administration


Take with full glass of water. 2 caplets every 6 hours as needed; max 8 caplets/day.


Not recommended.

Excedrin Extra Strength Contraindications


NSAID allergy. Varicella, vaccinia in children and teenagers. 3rd trimester of pregnancy.

Excedrin Extra Strength Boxed Warnings

Not Applicable

Excedrin Extra Strength Warnings/Precautions


Reye's syndrome. Persistent or unresponsive headache. Hypertension. Cardiovascular disease. Asthma. Peptic ulcer. GI bleeding disorders. Liver cirrhosis. Hepatic or renal impairment. Discontinue if signs/symptoms of GI bleed, tinnitus, loss of hearing, or new symptoms occur. Reevaluate if pain worsens or persists for >10 days or if fever worsens or persists for >3 days. Elderly (≥60yrs). Pregnancy. Nursing mothers.

Excedrin Extra Strength Pharmacokinetics

See Literature

Excedrin Extra Strength Interactions


May potentiate anticoagulants, hypoglycemics, methotrexate. May antagonize uricosurics. Increased risk of liver toxicity and/or GI bleed with ≥3 alcoholic drinks/day or concomitant other drugs containing acetaminophen, NSAIDs. Caution with diuretics, corticosteroids.

Excedrin Extra Strength Adverse Reactions

Adverse Reactions

Gastric upset, prolonged bleeding time, urticaria, anaphylaxis; overdosage: salicylism, hepatoxicity.

Excedrin Extra Strength Clinical Trials

See Literature

Excedrin Extra Strength Note

Not Applicable

Excedrin Extra Strength Patient Counseling

See Literature