• Poisoning/overdose

Evzio Generic Name & Formulations

General Description

Naloxone HCl 2mg/0.4mL; soln in a prefilled auto-injector for IM or SC inj; latex-free.

Pharmacological Class

Opioid antagonist.

How Supplied

Prefilled auto-injectors—2 (w. Trainer)


Evzio Indications


Emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or CNS depression.

Evzio Dosage and Administration

Adults and Children

<1yr: Pinch thigh muscle while administering; monitor inj site for residual needle parts and/or infection. ≥1yr: Inject IM or SC into the anterolateral aspect of the thigh (through clothing, if necessary) according to label instructions. All: may give additional doses every 2–3 mins until desired response or emergency medical assistance available. Repeated doses depending on amount, type, and route of administration of the opioid being antagonized may be required.

Evzio Contraindications

Not Applicable

Evzio Boxed Warnings

Not Applicable

Evzio Warnings/Precautions


Not a substitute for emergency medical care. Monitor patients with satisfactory response due to long duration of some narcotics. Have other resuscitative measures available. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Post-op use in pre-existing cardiac disorders; monitor. Neonates. Elderly. Pregnancy. Nursing mothers.

Evzio Pharmacokinetics

See Literature

Evzio Interactions


Caution with cardiotoxic drugs. Incomplete reversal of mixed agonists/antagonists (eg, buprenorphine, pentazocine); may require higher naloxone dose.

Evzio Adverse Reactions

Adverse Reactions

Dizziness, inj site erythema; precipitation of severe opioid withdrawal.

Evzio Clinical Trials

See Literature

Evzio Note

Not Applicable

Evzio Patient Counseling

See Literature