Evoxac Generic Name & Formulations
Cevimeline HCl 30mg; caps.
Mechanism of Action
Cevimeline is a cholinergic agonist which binds to muscarinic receptors. Muscarinic agonists in sufficient dosage can increase secretion of exocrine glands, such as salivary and sweat glands and increase tone of the smooth muscle in the gastrointestinal and urinary tracts.
Dry mouth associated with Sjogren's syndrome.
Evoxac Dosage and Administration
30mg three times daily.
Uncontrolled asthma. When miosis is undesirable (eg, acute iritis, narrow-angle glaucoma).
Evoxac Boxed Warnings
History of cardiovascular disease. Controlled asthma. Chronic bronchitis. COPD. History of nephrolithiasis or cholelithiasis. CYP2D6 deficiency. Pregnancy (Cat.C). Nursing mothers: not recommended.
Renal. Half-life: ~5 hours.
Potentiated by CYP2D6 and CYP3A3/4 inhibitors. Possible conduction disturbances with β-adrenergic antagonists. Additive effects with parasympathomimetics. May interfere with antimuscarinics.
Evoxac Adverse Reactions
Excessive sweating (dehydration may develop; drink extra water), rhinitis, excessive salivation, UTI, cough, arthralgia, fatigue, insomnia, hot flushes, GI upset, visual disturbances (eg, blurring, decreased visual acuity), others.
Evoxac Clinical Trials
Evoxac Patient Counseling