Etidronate Disodium Generic Name & Formulations
Etidronate disodium 200mg, 400mg; scored tabs.
Etidronate Disodium Indications
Treatment of symptomatic Paget's disease of bone. Prevention and treatment of heterotopic ossification after total hip replacement or due to spinal cord injury.
Etidronate Disodium Dosage and Administration
Swallow whole; take with a full glass of water (6–8oz) in upright position; do not lie down afterwards. Give once daily (preferred) or in divided doses at least 2hrs before or after food. Paget's: initially 5–10mg/kg/day; max 6 months (if ineffective, or if rapid bone turnover must be suppressed or to reduce elevated cardiac output: 11–20mg/kg/day; max 3 months). May retreat after 3 etidronate-free months if evidence of active disease process exists. Heterotopic ossification: hip replacement: 20mg/kg/day for 1 month before and 3 months after surgery; spinal cord injury: 20mg/kg/day for 2 weeks, then 10mg/kg/day for 10 weeks.
Etidronate Disodium Contraindications
Esophagus abnormalities which delay esophageal emptying (eg, stricture, achalasia). Clinically overt osteomalacia.
Etidronate Disodium Boxed Warnings
Etidronate Disodium Warnings/Precautions
Active upper GI disease; discontinue and reevaluate if signs/symptoms of esophageal reaction occur. Ensure adequate calcium and Vit. D intake. Risk of osteonecrosis of the jaw; consider discontinuing therapy during invasive dental procedures (eg, tooth extraction, implants, surgery). Enterocolitis. Osteomalacia and increased fracture risk in chronic use or high doses. Osteolytic lesions. Renal dysfunction: reduce dose. Pregnancy (Cat.C). Nursing mothers.
Etidronate Disodium Pharmacokinetics
Etidronate Disodium Interactions
Calcium, aluminum- or magnesium-containing antacids, iron, other divalent cations reduce absorption (separate dosing by >2hrs). Monitor warfarin.
Etidronate Disodium Adverse Reactions
Diarrhea, nausea, musculoskeletal pain, esophagitis, esophageal ulcers/erosions, gastritis (may be severe); osteomalacia, bone fractures, jaw osteonecrosis.
Etidronate Disodium Clinical Trials
Etidronate Disodium Note
Formerly known under the brand name Didronel.
Etidronate Disodium Patient Counseling