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Escitalopram Oral Solution Generic Name & Formulations
Legal Class
Rx
General Description
Escitalopram (as oxalate) 1mg/mL; peppermint flavor; contains parabens.
Pharmacological Class
SSRI.
See Also
How Supplied
Tabs—100; Soln—contact supplier
Manufacturer
Escitalopram Oral Solution Indications
Indications
Generalized anxiety disorder.
Escitalopram Oral Solution Dosage and Administration
Adult
Initially 10mg once daily; may increase to 20mg once daily after 1 week. Elderly or hepatic impairment: 10mg once daily.
Children
<18yrs: not established.
Escitalopram Oral Solution Contraindications
Contraindications
During or within 14 days of MAOIs; do not start an MAOI during or within 14 days of escitalopram. Concomitant pimozide, linezolid, IV methylene blue.
Escitalopram Oral Solution Boxed Warnings
Boxed Warning
Suicidality and antidepressant drugs.
Escitalopram Oral Solution Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. History of seizures or mania/hypomania. Monitor for serotonin syndrome; discontinue if occurs. Hepatic or severe renal impairment (CrCl <20mL/min). Angle-closure glaucoma. Conditions that affect metabolic or hemodynamic responses. Recent MI. Unstable heart disease. Volume-depleted. Hyponatremia (esp. elderly). Sexual dysfunction. Avoid abrupt cessation. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (during 3rd trimester; see full labeling for effects on neonate). Nursing mothers: monitor.
Escitalopram Oral Solution Pharmacokinetics
See Literature
Escitalopram Oral Solution Interactions
Interactions
See Contraindications. Do not give with citalopram. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Increased risk of bleeding with concomitant NSAIDs, aspirin, warfarin, and others that affect coagulation. May be antagonized by carbamazepine. Caution with drugs metabolized by CYP2D6 or other centrally-acting drugs. Increases metoprolol levels.
Escitalopram Oral Solution Adverse Reactions
Adverse Reactions
Insomnia, ejaculation disorder, nausea, increased sweating, fatigue, somnolence, decreased libido, anorgasmia.
Escitalopram Oral Solution Clinical Trials
See Literature
Escitalopram Oral Solution Note
Not Applicable
Escitalopram Oral Solution Patient Counseling
See Literature
Escitalopram Oral Solution Generic Name & Formulations
Legal Class
Rx
General Description
Escitalopram (as oxalate) 1mg/mL; peppermint flavor; contains parabens.
Pharmacological Class
SSRI.
See Also
How Supplied
Tabs—100; Soln—contact supplier
Manufacturer
Escitalopram Oral Solution Indications
Indications
Major depressive disorder.
Escitalopram Oral Solution Dosage and Administration
Adult
Initially 10mg once daily; may increase to 20mg once daily after 1 week. Elderly or hepatic impairment: 10mg once daily.
Children
<12yrs: not established. 12–17yrs: initially 10mg once daily; may increase to 20mg once daily after 3 weeks.
Escitalopram Oral Solution Contraindications
Contraindications
During or within 14 days of MAOIs; do not start an MAOI during or within 14 days of escitalopram. Concomitant pimozide, linezolid, IV methylene blue.
Escitalopram Oral Solution Boxed Warnings
Boxed Warning
Suicidality and antidepressant drugs.
Escitalopram Oral Solution Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. History of seizures or mania/hypomania. Monitor for serotonin syndrome; discontinue if occurs. Hepatic or severe renal impairment (CrCl <20mL/min). Angle-closure glaucoma. Conditions that affect metabolic or hemodynamic responses. Recent MI. Unstable heart disease. Volume-depleted. Hyponatremia (esp. elderly). Sexual dysfunction. Avoid abrupt cessation. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (during 3rd trimester; see full labeling for effects on neonate). Nursing mothers: monitor.
Escitalopram Oral Solution Pharmacokinetics
See Literature
Escitalopram Oral Solution Interactions
Interactions
See Contraindications. Do not give with citalopram. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Increased risk of bleeding with concomitant NSAIDs, aspirin, warfarin, and others that affect coagulation. May be antagonized by carbamazepine. Caution with drugs metabolized by CYP2D6 or other centrally-acting drugs. Increases metoprolol levels.
Escitalopram Oral Solution Adverse Reactions
Adverse Reactions
Insomnia, ejaculation disorder, nausea, increased sweating, fatigue, somnolence, decreased libido, anorgasmia.
Escitalopram Oral Solution Clinical Trials
See Literature
Escitalopram Oral Solution Note
Not Applicable
Escitalopram Oral Solution Patient Counseling
See Literature
