Erythromycin Ophthalmic Ointment

  • Ocular infections

Erythromycin Ophthalmic Ointment Generic Name & Formulations

General Description

Erythromycin 5mg/g.

Pharmacological Class


How Supplied


How Supplied

Sterile Erythromycin Ophthalmic Ointment USP, 5 mg/g as follows: 3.5g (1/8oz) tamper-evident tubes.


Store at controlled room temperature 15°-30°C (59°-86°F). Avoid excessive heat. Protect from freezing.


Erythromycin Ophthalmic Ointment Indications


Susceptible infections of conjunctiva and cornea.


For the treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by organisms susceptible to erythromycin.

For prophylaxis of ophthalmia neonatorum due to N. gonorrhoeae or C. trachomatis. The effectiveness of erythromycin in the prevention of ophthalmia caused by penicillinase-producing N. gonorrheae is not established.

For infants born to mothers with clinically apparent gonorrhea, intravenous or intramuscular injections of aqueous crystalline penicillin G should be given; a single dose of 50,000 units for term infants or 20,000 units for infants of low birth weight. Topical prophylaxis alone is inadequate for these infants.

Erythromycin Ophthalmic Ointment Dosage and Administration

Adults and Children

Apply 1cm ribbon of ointment to infected area up to 6 times daily. Prophylaxis of neonatal gonoccocal or chlamydial conjunctivitis: instill 1cm ribbon of ointment into each lower conjunctival sac.

Erythromycin Ophthalmic Ointment Contraindications

Not Applicable

Erythromycin Ophthalmic Ointment Boxed Warnings

Not Applicable

Erythromycin Ophthalmic Ointment Warnings/Precautions


Pregnancy (Cat.B). Nursing mothers.


The use of antimicrobial agents may be associated with the overgrowth of nonsusceptible organisms including fungi; in such a case, antibiotic administration should be stopped and appropriate measures taken.

Avoid contaminating the applicator tip with material from the eye, fingers, or other source.

Two year oral studies conducted in rats with erythromycin did not provide evidence of tumorigenicity. Mutagenicity studies have not been conducted.

No evidence of impaired fertility that appeared related to erythromycin was reported in animal studies.

Pregnancy Considerations

Teratogenic Effects: Pregnancy Category B

  • No evidence of harm to the fetus that appeared related to erythromycin was reported in these studies. There are, however, no adequate and well controlled studies in pregnant women. Because animal reproductive studies are not always predictive of human response, the erythromycins should be used during pregnancy only if clearly needed.

Nursing Mother Considerations

Use caution when erythromycin is administered to a nursing woman.

Erythromycin Ophthalmic Ointment Pharmacokinetics


Hepatic. ~93% serum protein bound.

Erythromycin Ophthalmic Ointment Interactions

Erythromycin Ophthalmic Ointment Adverse Reactions

Adverse Reactions

Ocular irritation, redness; hypersensivity reactions, superinfection.

Erythromycin Ophthalmic Ointment Clinical Trials

See Literature

Erythromycin Ophthalmic Ointment Note

Not Applicable

Erythromycin Ophthalmic Ointment Patient Counseling

Patient Counseling

Avoid contaminating the applicator tip with material from the eye, fingers, or other source.