Migraine and headache:
Indications for: Ergotamine tartrate + Caffeine Suppositories
Migraine, migraine variants, cluster headaches.
Adult Dosage:
1 supp rectally at onset of attack, then 1 supp after 1 hour if needed; max 2 supps/attack, 5 supps/week.
Children Dosage:
Not recommended.
Ergotamine tartrate + Caffeine Suppositories Contraindications:
Peripheral vascular disease. Coronary heart disease. Hypertension. Hepatic or renal dysfunction. Sepsis. Concomitant potent CYP3A4 inhibitors (eg, ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) or other vasoconstrictors. Labor & delivery. Pregnancy (Cat.X).
Ergotamine tartrate + Caffeine Suppositories Warnings/Precautions:
Monitor for ergotism; do not exceed recommended dose. Nursing mothers: not recommended.
See Also:
Ergotamine tartrate + Caffeine Suppositories Classification:
Ergot alkaloid.
Ergotamine tartrate + Caffeine Suppositories Interactions:
See Contraindications. Potentiated by CYP3A4 inhibitors (eg, protease inhibitors, macrolides, azole antifungals, saquinavir, nefazodone, fluoxetine, fluvoxamine, grapefruit juice, zileuton), propranolol, nicotine. Severe hypertension with sympathomimetics.
Adverse Reactions:
Vasoconstrictive complications or ergotism (eg, ischemia, cold extremities, vasospasm, ECG changes, hyper- or hypotension, numbness, gangrene, dizziness), precordial or muscle pain, tachycardia, bradycardia, nausea, vomiting, local edema, itching; rarely: retroperitoneal and pleuropulmonary fibrosis, cardiac valve fibrosis (chronic use).
Note:
Formerly known under the brand names Cafergot, Migergot.
How Supplied:
Contact supplier.