Migraine and headache:

Indications for Ergotamine tartrate + Caffeine Suppositories:

Migraine, migraine variants, cluster headaches.

Adult:

1 supp rectally at onset of attack, then 1 supp after 1 hour if needed; max 2 supps/attack, 5 supps/week.

Children:

Not recommended.

Contraindications:

Peripheral vascular disease. Coronary heart disease. Hypertension. Hepatic or renal dysfunction. Sepsis. Concomitant potent CYP3A4 inhibitors (eg, ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) or other vasoconstrictors. Labor & delivery. Pregnancy (Cat.X).

Warnings/Precautions:

Monitor for ergotism; do not exceed recommended dose. Nursing mothers: not recommended.

See Also:

Pharmacologic Class:

Ergot alkaloid.

Interactions:

See Contraindications. Potentiated by CYP3A4 inhibitors (eg, protease inhibitors, macrolides, azole antifungals, saquinavir, nefazodone, fluoxetine, fluvoxamine, grapefruit juice, zileuton), propranolol, nicotine. Severe hypertension with sympathomimetics.

Adverse Reactions:

Vasoconstrictive complications or ergotism (eg, ischemia, cold extremities, vasospasm, ECG changes, hyper- or hypotension, numbness, gangrene, dizziness), precordial or muscle pain, tachycardia, bradycardia, nausea, vomiting, local edema, itching; rarely: retroperitoneal and pleuropulmonary fibrosis, cardiac valve fibrosis (chronic use).

Note:

Formerly known under the brand names Cafergot, Migergot.

How Supplied:

Contact supplier.