• Anaphylaxis

Epipen Generic Name & Formulations

General Description

Epinephrine 0.3mg (1:1000); prefilled auto-injector; contains sulfites.

Pharmacological Class


See Also

How Supplied



Generic Availability


Epipen Indications


Emergency treatment of allergic reactions (Type 1) including anaphylaxis.

Epipen Dosage and Administration

Adults and Children

Inject IM or SQ only into the anterolateral aspect of the thigh. <15kg: not studied. 15–30kg: 0.15mg. ≥30kg: 0.3mg. May repeat another dose if needed.

Epipen Contraindications

Not Applicable

Epipen Boxed Warnings

Not Applicable

Epipen Warnings/Precautions


The presence of sulfite in this product should not deter use. Cardiovascular disease. Hypertension. Hyperthyroidism. Diabetes. Parkinson's disease. Injection-related complications: do not inject intravenously or into buttock (risk of Clostridial infections), digits, hands, or feet; hold leg firmly and limit movement in children prior to and during injection. Advise patient to seek medical help immediately. Train patient in use of device. Elderly. Pregnancy. Nursing mothers.

Epipen Pharmacokinetics

See Literature

Epipen Interactions


May be potentiated by MAOIs, tricyclic antidepressants, levothyroxine, antihistamines (eg, chlorpheniramine, tripelennamine, diphenhydramine). May be antagonized by β-blockers (eg, propranolol), α-blockers (eg, phentolamine), ergot alkaloids. Arrhythmias possible with cardiac glycosides, diuretics, or anti-arrhythmics.

Epipen Adverse Reactions

Adverse Reactions

Anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea, vomiting, headache, respiratory difficulties; arrhythmias; rare: serious infections (skin and soft tissue) at injection site, stress cardiomyopathy.

Epipen Clinical Trials

See Literature

Epipen Note

Not Applicable

Epipen Patient Counseling

See Literature