• Imaging agents

Eovist Generic Name & Formulations

General Description

Gadoxetate disodium 181.43mg/mL (0.25mmol/mL); soln for IV inj; preservative-free.

Pharmacological Class

Gadolinium-based contrast agent.

How Supplied

Single-dose vials (10mL, 15mL)—5


Eovist Indications


For use in MRI of the liver to detect and characterize lesions in patients with known or suspected focal liver disease.

Eovist Dosage and Administration

Adults and Children

Premature infants: not established. Give as IV bolus inj at a rate of ~2mL/sec. 0.1mL/kg (0.025mmol/kg); flush IV cannula with normal saline after inj. See full labeling re: imaging guidelines.

Eovist Contraindications

Not Applicable

Eovist Boxed Warnings

Boxed Warning

Nephrogenic systemic fibrosis.

Eovist Warnings/Precautions


Increased risk of nephrogenic systemic fibrosis in chronic kidney disease or acute kidney injury; avoid use. Screen for renal dysfunction. Do not exceed recommended dose and allow sufficient time for drug elimination before re-administration. Have emergency resuscitative equipment available. History of asthma or other allergic disorders. Monitor for signs/symptoms of hypersensitivity reactions during and after administration. Increased risk of gadolinium retention with multiple lifetime doses, in pregnant patients, children, and those with inflammatory conditions; minimize repetitive imaging studies. Elevated bilirubin (>3mg/dL) or ferritin may reduce hepatic contrast effect; perform MRI no later than 60mins following administration. Avoid extravasation. Severe renal or hepatic failure. Elderly. Pregnancy. Nursing mothers: consider interrupting nursing and pumping/discarding breast milk for up to 10hrs after inj.

Eovist Pharmacokinetics

See Literature

Eovist Interactions


Serum iron using complexometric methods may result in falsely high or low values for up to 24hrs.

Eovist Adverse Reactions

Adverse Reactions

Nausea, headache, feeling hot, dizziness, back pain; hypersensitivity reactions.

Eovist Clinical Trials

See Literature

Eovist Note

Not Applicable

Eovist Patient Counseling

See Literature