ENTYVIO

Entyvio Generic Name & Formulations

Legal Class

General Description

Vedolizumab 300mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; preservative-free.

Pharmacological Class

Integrin receptor antagonist.

How Supplied

Single-use vial (20mL)—1

Manufacturer

Takeda Pharmaceutical Company

Generic Availability

Entyvio Indications

Indications

Moderately to severely active ulcerative colitis or Crohn’s disease.

Entyvio Dosage and Administration

Adult

Give by IV infusion over 30mins. ≥18yrs: 300mg at Weeks 0, 2, and 6, then every 8 weeks thereafter. Discontinue if no therapeutic benefit by Week 14.

Children

<18yrs: not established.

Entyvio Contraindications

Not Applicable

Entyvio Boxed Warnings

Not Applicable

Entyvio Warnings/Precautions

Warnings/Precautions

Complete all immunizations according to current guidelines before initiating. Monitor for hypersensitivity reactions during and after infusion. Have epinephrine and antihistamines available. Discontinue if anaphylaxis or other serious infusion-related or hypersensitivity reactions occur. Active, severe infections: not recommended until controlled. Consider withholding if severe infection develops. History of recurring severe infections. Consider tuberculosis screening. Monitor for neurological signs/symptoms (those associated with progressive multifocal leukoencephalopathy [PML]); withhold dosing if suspected; permanently discontinue if confirmed. Discontinue if jaundice or significant liver injury occurs. Pregnancy. Nursing mothers.

Entyvio Pharmacokinetics

See Literature

Entyvio Interactions

Interactions

Avoid concomitant natalizumab, TNF blockers. Caution with concomitant live vaccines.

Entyvio Adverse Reactions

Adverse Reactions

Nasopharyngitis, headache, arthralgia, nausea, pyrexia, upper respiratory tract infection, fatigue, cough, bronchitis, influenza, back pain, rash, pruritus, sinusitis, oropharyngeal pain, pain in extremities; infusion-related or hypersensitivity reactions, PML.

Entyvio

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