Select therapeutic use:

Breast cancer:

Indications for: ENHERTU

Treatment of unresectable or metastatic HER2-positive breast cancer in patients who have received ≥2 prior anti-HER2-based regimens in the metastatic setting.

Adult Dosage:

Give as IV infusion over 90mins; may give subsequent infusions over 30mins if prior infusions tolerated. 5.4mg/kg once every 3 weeks (21-day cycle) until disease progression or unacceptable toxicity. Dose modifications: see full labeling.

Children Dosage:

Not established.

Boxed Warning:

Interstitial lung disease. Embryo-fetal toxicity.

ENHERTU Warnings/Precautions:

Not substitutable for or with trastuzumab or ado-trastuzumab emtansine. Monitor for new or worsening respiratory symptoms; permanently discontinue if grade ≥2 interstitial lung disease (ILD)/pneumonitis develops. Monitor CBCs prior to initiation and each dose, then as clinically indicated; interrupt or reduce dose based on severity of neutropenia. Risk of left ventricular dysfunction. Assess LVEF prior to initiation and at regular intervals during treatment as clinically indicated; permanently discontinue if LVEF <40% or absolute decrease from baseline >20% is confirmed. Permanently discontinue in patients with symptomatic CHF or if severe infusion reactions occur. Moderate hepatic impairment: monitor closely. Severe renal or hepatic impairment: no data. Embryo-fetal toxicity (oligohydramnios, others). Advise to use effective contraception during and for ≥7 months (females) or ≥4 months (males w. female partners) after the last dose. Pregnancy: exclude status prior to initiation. Nursing mothers: not recommended (during and for 7 months after the last dose).

ENHERTU Classification:

HER2-directed antibody + topoisomerase inhibitor conjugate.

Adverse Reactions:

Nausea, decreased blood counts (WBC, hemoglobin, neutrophil, platelet, lymphocyte), fatigue, vomiting, alopecia, increased AST/ALT, constipation, decreased appetite, anemia, diarrhea, hypokalemia, cough, increased blood alkaline phosphatase, increased blood bilirubin, pyrexia.

Generic Drug Availability:

NO

How Supplied:

Single-dose vial—1

Pricing for ENHERTU

100mg vial (Qty: 1)
Appx. price $2422
GoodRx

Colorectal and other GI cancers:

Indications for: ENHERTU

Treatment of locally advanced or metastatic HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma in patients who have received a prior trastuzumab-based regimen.

Adult Dosage:

Give as IV infusion over 90mins; may give subsequent infusions over 30mins if prior infusions tolerated. 6.4mg/kg once every 3 weeks (21-day cycle) until disease progression or unacceptable toxicity. Dose modifications: see full labeling.

Children Dosage:

Not established.

Boxed Warning:

Interstitial lung disease. Embryo-fetal toxicity.

ENHERTU Warnings/Precautions:

Not substitutable for or with trastuzumab or ado-trastuzumab emtansine. Monitor for new or worsening respiratory symptoms; permanently discontinue if grade ≥2 interstitial lung disease (ILD)/pneumonitis develops. Monitor CBCs prior to initiation and each dose, then as clinically indicated; interrupt or reduce dose based on severity of neutropenia. Risk of left ventricular dysfunction. Assess LVEF prior to initiation and at regular intervals during treatment as clinically indicated; permanently discontinue if LVEF <40% or absolute decrease from baseline >20% is confirmed. Permanently discontinue in patients with symptomatic CHF or if severe infusion reactions occur. Moderate hepatic impairment: monitor closely. Severe renal or hepatic impairment: no data. Embryo-fetal toxicity (oligohydramnios, others). Advise to use effective contraception during and for ≥7 months (females) or ≥4 months (males w. female partners) after the last dose. Pregnancy: exclude status prior to initiation. Nursing mothers: not recommended (during and for 7 months after the last dose).

ENHERTU Classification:

HER2-directed antibody + topoisomerase inhibitor conjugate.

Adverse Reactions:

Nausea, decreased blood counts (WBC, hemoglobin, neutrophil, platelet, lymphocyte), fatigue, vomiting, alopecia, increased AST/ALT, constipation, decreased appetite, anemia, diarrhea, hypokalemia, cough, increased blood alkaline phosphatase, increased blood bilirubin, pyrexia.

Generic Drug Availability:

NO

How Supplied:

Single-dose vial—1

Pricing for ENHERTU

100mg vial (Qty: 1)
Appx. price $2422
GoodRx