Enalaprilat Injection

  • Hypertension

Enalaprilat Injection Generic Name & Formulations

General Description

Enalaprilat 1.25mg/mL; soln for IV inj.

Pharmacological Class

ACE inhibitor.

How Supplied

Contact supplier.

Enalaprilat Injection Indications


To reduce blood pressure when oral therapy is not practical.

Enalaprilat Injection Dosage and Administration


Give by IV inj over 5 minutes (administer over a longer period of time [up to 1 hour] in patients at risk for excessive hypotension). 1.25mg every 6 hours; max 20mg/day. Concomitant diuretics or CrCl≤30mL/min: initially 0.625mg; if inadequate response after 1 hour, may give additional 0.625mg dose; additional doses of 1.25mg may be given every 6 hours thereafter.


Not recommended.

Enalaprilat Injection Contraindications


History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters).

Enalaprilat Injection Boxed Warnings

Not Applicable

Enalaprilat Injection Warnings/Precautions


Renal or hepatic impairment. Salt/volume depletion. Severe CHF. Renal artery or aortic stenosis. Hypertrophic cardiomyopathy. Monitor for neutropenia in renal or collagen vascular disease. Monitor for hyperkalemia in diabetics. Dialysis. Surgery. Discontinue if laryngeal edema, angioedema, marked elevations of liver enzymes or jaundice occurs. Black patients may have higher risk of angioedema than non-black patients. Elderly. Pregnancy (Cat.C in 1st trimester). Nursing mothers.

Enalaprilat Injection Pharmacokinetics

See Literature

Enalaprilat Injection Interactions


Hypotension with diuretics. Hyperkalemia with K+-sparing diuretics or K+ supplements. May increase lithium levels. May be antagonized by NSAIDS.

Enalaprilat Injection Adverse Reactions

Adverse Reactions

Headache, orthostatic hypotension, asthenia, hyperkalemia, renal impairment, nausea, cough; angioedema, liver dysfunction, blood dyscrasias (rare).

Enalaprilat Injection Clinical Trials

See Literature

Enalaprilat Injection Note


Formerly known under the brand name Vasotec.

Enalaprilat Injection Patient Counseling

See Literature