Enablex Generic Name & Formulations
Darifenacin (as HBr) 7.5mg, 15mg; ext-rel tabs.
Overactive bladder with symptoms of urge urinary incontinence, urgency and frequency.
Enablex Dosage and Administration
Swallow whole with liquid. Initially 7.5mg once daily; may increase to 15mg once daily after 2 weeks. Moderate hepatic impairment (Child-Pugh B), concomitant potent CYP3A4 inhibitors: max 7.5mg once daily.
Patients with or at risk for: urinary or gastric retention, uncontrolled narrow-angle glaucoma.
Enablex Boxed Warnings
Severe hepatic impairment: not recommended. Bladder outflow obstruction. GI obstruction. Severe constipation. Ulcerative colitis. Myasthenia gravis. Controlled narrow-angle glaucoma. Monitor for CNS effects esp. after initiation or dose increases; consider reducing dose or discontinue if occurs. High environmental temperatures. Pregnancy. Nursing mothers.
Renal (60%), fecal (40%). Half-life: 13–19 hours.
Potentiated by potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin, nefazadone); see Adult. May potentiate CYP2D6 substrates with narrow therapeutic indexes (eg, flecainide, thioridazine, TCAs). Additive anticholinergic effects with other anticholinergics.
Enablex Adverse Reactions
Constipation, dry mouth, headache, dyspepsia, nausea, UTI, accidental injury, flu symptoms; angioedema (discontinue if occurs), CNS effects (eg, confusion, hallucination, somnolence).
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