• Anesthetics

Emerphed Generic Name & Formulations

General Description

Ephedrine sulfate 5mg/mL; premixed soln for IV inj.

Pharmacological Class


How Supplied

Single-dose vials (10mL), single-dose prefilled syringes (5mL, 10mL)—10


Generic Availability


Mechanism of Action

Ephedrine sulfate acts directly as an agonist at alpha- and beta-adrenergic receptors and indirectly causes the release of norepinephrine from sympathetic neurons. Pressor effects by direct alpha- and beta-adrenergic receptor activation are mediated by increases in arterial pressures, cardiac output, and peripheral resistance. Ephedrine sulfate stimulates heart rate and cardiac output and variably increases peripheral resistance, resulting in increased blood pressure.

Emerphed Indications


Treatment of clinically important hypotension occurring in the setting of anesthesia.

Emerphed Dosage and Administration


Do not dilute. Give as IV bolus. Initially 5–10mg, may repeat as needed; max total dose: 50mg.


Not established.

Emerphed Contraindications

Not Applicable

Emerphed Boxed Warnings

Not Applicable

Emerphed Warnings/Precautions


Tolerance may develop. Repeated doses may cause tachyphylaxis. Have alternative pressor agent readily available. Hypertension. Renal impairment: monitor. Elderly. Pregnancy. Nursing mothers.

Emerphed Pharmacokinetics



Emerphed Interactions


Severe postpartum hypertension with concomitant oxytocics (eg, methylergonovine, ergonovine); monitor. Potentiated by MAOIs, clonidine, propofol, atropine; monitor. Antagonized by alpha-blockers, beta-blockers, reserpine, quinidine, mephentermine; monitor. May inhibit hypotensive effect of guanethidine; monitor and adjust dose. May reduce onset time of neuromuscular blockade when used for intubation with rocuronium if used simultaneously. May decrease efficacy of epidural blockade; monitor. Concomitant theophylline may increase frequency of nausea, nervousness, and insomnia. Concomitant digitalis glycosides may cause cardiac arrhythmias; monitor.

Emerphed Adverse Reactions

Adverse Reactions

Nausea, vomiting, tachycardia, palpitations, reactive hypertension, bradycardia, dizziness, restlessness.

Emerphed Clinical Trials

See Literature

Emerphed Note

Not Applicable

Emerphed Patient Counseling

See Literature