Anesthetics:

Indications for EMERPHED:

Treatment of clinically important hypotension occurring in the setting of anesthesia.

Adult:

Do not dilute. Give as IV bolus. Initially 5–10mg, may repeat as needed; max total dose: 50mg.

Children:

Not established.

Warnings/Precautions:

Tolerance may develop. Repeated doses may cause tachyphylaxis. Have alternative pressor agent readily available. Hypertension. Renal impairment: monitor. Elderly. Pregnancy. Nursing mothers.

Pharmacologic Class:

Sympathomimetic.

Interactions:

Severe hypertension with concomitant oxytocics (eg, methylergonovine, ergonovine); monitor. Potentiated by MAOIs, clonidine, propofol, atropine; monitor. Antagonized by alpha-blockers, beta-blockers, reserpine, quinidine, mephentermine; monitor. May inhibit hypotensive effect of guanethidine; monitor and adjust dose. May reduce onset time of neuromuscular blockade when used for intubation with rocuronium if used simultaneously. May decrease efficacy of epidural blockade; monitor. Concomitant theophylline may increase frequency of nausea, nervousness, and insomnia. Concomitant digitalis glycosides may cause cardiac arrhythmias; monitor.

Adverse Reactions:

Nausea, vomiting, tachycardia, palpitations, reactive hypertension, bradycardia, dizziness, restlessness.

Generic Availability:

NO

How Supplied:

Single-dose vial—1, 10