Emend For Oral Suspension

  • Nausea

Emend For Oral Suspension Generic Name & Formulations

General Description

Aprepitant 125mg; per pouch; pwd for oral susp after reconstitution.

Pharmacological Class

Substance P/NK1 receptor antagonist.

How Supplied

Caps—6; Bi-fold pack (2 x 80mg)—1; Tri-fold pack (1 x 125mg + 2 x 80mg)—1; Susp kit—1 (w. oral dispensers, supplies); Single-dose vial—1


Generic Availability


Emend For Oral Suspension Indications


In combination with other antiemetic agents, in patients ≥6mos of age for prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately to highly emetogenic cancer chemotherapy, including high-dose cisplatin.

Emend For Oral Suspension Dosage and Administration

Adults and Children

<6mos or <6kg: not recommended. Give with corticosteroid and 5-HT3 antagonist (see full labeling). 6mos–<12yrs or patients (Peds or Adults) unable to swallow: 3mg/kg (max 125mg) on Day 1; then 2mg/kg (max 80mg) on Days 2 and 3. Administer susp 1hr prior to chemotherapy on Days 1, 2, and 3; if no chemotherapy is given on Days 2 and 3, administer susp in the AM.

Emend For Oral Suspension Contraindications


Concomitant pimozide.

Emend For Oral Suspension Boxed Warnings

Not Applicable

Emend For Oral Suspension Warnings/Precautions


Not for chronic continuous use. Severe hepatic impairment. Injection: monitor for infusion site or hypersensitivity reactions; discontinue and treat appropriately if occur; do not reinitiate if symptoms (eg, flushing, erythema, dyspnea, hypotension, syncope) develop with first-time use. Avoid infusion into small veins or through a butterfly catheter. Elderly. Advise females of reproductive potential using hormonal contraceptives to use an effective alternative or back-up non-hormonal contraceptive (see Interactions). Pregnancy. Nursing mothers.

Emend For Oral Suspension Pharmacokinetics

See Literature

Emend For Oral Suspension Interactions


See Contraindications. Monitor, and caution with, CYP3A4 substrates, including chemotherapy agents (eg, ifosfamide, vinblastine, vincristine). Avoid concomitant moderate-to-strong CYP3A4 inhibitors (eg, azole antifungals, macrolides, nefazodone, ritonavir, nelfinavir, diltiazem) or strong CYP3A4 inducers (eg, carbamazepine, phenytoin, rifampin). Potentiates dexamethasone (reduce its dose by 50%), methylprednisolone (reduce its IV dose by 25% and its oral dose by 50%), midazolam, alprazolam, triazolam. May antagonize warfarin (closely monitor INR for 2 weeks after starting each regimen), other CYP2C9 substrates, oral contraceptives (use alternative or backup method during and for 1 month after last dose).

Emend For Oral Suspension Adverse Reactions

Adverse Reactions

Fatigue, diarrhea, asthenia, dyspepsia, abdominal pain, hiccups, WBC count decreased, dehydration, ALT/AST increased, neutropenia, headache, anorexia, cough, hemoglobin decreased, dizziness, constipation, hypotension. Injection: also anemia, peripheral neuropathy, UTI, extremity pain, infusion-site reactions, anaphylaxis.

Emend For Oral Suspension Clinical Trials

See Literature

Emend For Oral Suspension Note

Not Applicable

Emend For Oral Suspension Patient Counseling

See Literature