Pituitary disorders:

Indications for EGRIFTA:

For the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy.

Limitations of Use:

Long-term cardiovascular benefit and safety have not been studied. Not for use in weight loss management. No data to support improved compliance with anti-retroviral therapies in HIV (+) patients.


Give by SC inj. Inject into abdomen, rotate inj sites. 2mg once daily.


Not established.


Disruption of hypothalmic-pituitary axis due to hypophysectomy, hypopituitarism, pituitary tumors/surgery, head irradiation, or head trauma. Active malignancy. Pregnancy.


History of treated and stable malignancies. Fluid retention. Discontinue in critically ill patients. Monitor IGF-1 levels closely; consider discontinuing if IGF-1 levels persistently elevated (eg, >3 SDS). Increased risk of impaired glucose tolerance or diabetes; monitor for changes in glucose metabolism. Monitor for worsening retinopathy in diabetic patients. Nursing mothers: not recommended.

See Also:

Pharmacologic Class:

Growth hormone releasing factor analogue.


Caution with concomitant drugs metabolized by CYP450 (eg, corticosteroids, sex steroids, anticonvulsants, cyclosporine). May inhibit 11β-hydroxysteroid dehydrogenase type 1; may need to increase maintenance and stress doses of glucocorticoid if needed for replacement in hypoadrenalism.

Adverse Reactions:

Arthralgia, inj site erythema/pruritus, extremity pain, peripheral edema, hyperglycemia, myalgia, carpal tunnel syndrome; glucose intolerance, hypersensitivity reactions.

Generic Availability:


How Supplied:

Egrifta—60 (vials w. diluent + supplies); Egrifta SV—30 (vials w. diluent + supplies)

Pricing for EGRIFTA

60 vials of 1mg box (Qty: 1)
Appx. price $5861