Efudex Cream

— THERAPEUTIC CATEGORIES —
  • Actinic keratoses
  • Melanoma and other skin cancers

Efudex Cream Generic Name & Formulations

General Description

Fluorouracil 5%.

Pharmacological Class

Antimetabolite.

See Also

How Supplied

Soln (w. drop dispenser)—10mL, 25mL; Crm—40g

Generic Availability

YES

Efudex Cream Indications

Indications

Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see full labeling.

Efudex Cream Dosage and Administration

Adult

Keratoses: Apply twice daily until erosion occurs (usually 2–4 wks). Basal cell carcinoma (5% only): Apply twice daily, usually for 3–6 weeks (obliteration may take 10–12 weeks).

Children

Not established.

Efudex Cream Contraindications

Contraindications

Dihydropyrimidine dehydrogenase (DPD) deficiency. Pregnancy.

Efudex Cream Boxed Warnings

Not Applicable

Efudex Cream Warnings/Precautions

Warnings/Precautions

Do not apply into eyes, nose, or mouth. Avoid mucous membranes, occlusion, ulcerated/inflamed skin, exposure to UV light. Wash hands after application if fingers were used. Advise patients of expected skin reaction. Biopsy unresponsive lesions. Nursing mothers: not recommended.

Efudex Cream Pharmacokinetics

See Literature

Efudex Cream Interactions

Efudex Cream Adverse Reactions

Adverse Reactions

Burning, crusting, allergic contact dermatitis, pruritus, scarring, rash, soreness, ulceration; leukocytosis.

Efudex Cream Clinical Trials

See Literature

Efudex Cream Note

Not Applicable

Efudex Cream Patient Counseling

See Literature

Efudex Cream Generic Name & Formulations

General Description

Fluorouracil 5%.

Pharmacological Class

Antimetabolite.

See Also

How Supplied

Soln (w. drop dispenser)—10mL, 25mL; Crm—40g

Generic Availability

YES

Efudex Cream Indications

Indications

Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see full labeling.

Efudex Cream Dosage and Administration

Adult

Keratoses: Apply twice daily until erosion occurs (usually 2–4 wks). Basal cell carcinoma (5% only): Apply twice daily, usually for 3–6 weeks (obliteration may take 10–12 weeks).

Children

Not established.

Efudex Cream Contraindications

Contraindications

Dihydropyrimidine dehydrogenase (DPD) deficiency. Pregnancy.

Efudex Cream Boxed Warnings

Not Applicable

Efudex Cream Warnings/Precautions

Warnings/Precautions

Do not apply into eyes, nose, or mouth. Avoid mucous membranes, occlusion, ulcerated/inflamed skin, exposure to UV light. Wash hands after application if fingers were used. Advise patients of expected skin reaction. Biopsy unresponsive lesions. Nursing mothers: not recommended.

Efudex Cream Pharmacokinetics

See Literature

Efudex Cream Interactions

Efudex Cream Adverse Reactions

Adverse Reactions

Burning, crusting, allergic contact dermatitis, pruritus, scarring, rash, soreness, ulceration; leukocytosis.

Efudex Cream Clinical Trials

See Literature

Efudex Cream Note

Not Applicable

Efudex Cream Patient Counseling

See Literature