E.e.s. Granules

  • Bacterial infections

E.e.s. Granules Generic Name & Formulations

General Description

Erythromycin (as ethylsuccinate) 200mg/5mL; for susp; cherry flavor.

Pharmacological Class


How Supplied

Granules—100mL, 200mL; Tabs—100

E.e.s. Granules Indications


Treatment of susceptible infections including upper and lower respiratory, skin and skin structure, genitourinary, Legionnaires' disease, pertussis, listeriosis. Prophylaxis for rheumatic fever attacks in penicillin-allergic patients.

E.e.s. Granules Dosage and Administration


1.6g/day in 2, 3, or 4 evenly divided doses; max 4g/day. Legionnaires: 1.6–4g/day in divided doses. Prophylaxis: 400mg twice daily. See full labeling.


Mild-to-moderate infections: 30–50mg/kg/day in 2, 3, or 4 evenly divided doses; may double dose in severe infections. See full labeling.

E.e.s. Granules Contraindications


Concomitant terfenadine, astemizole, cisapride, pimozide, ergotamine, dihydroergotamine, statins (eg, lovastatin, simvastatin).

E.e.s. Granules Boxed Warnings

Not Applicable

E.e.s. Granules Warnings/Precautions


Avoid in proarrhythmic conditions (eg, uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia); risk of QT prolongation. Myasthenia gravis. Hepatic impairment. Elderly. Infants: risk of infantile hypertrophic pyloric stenosis; monitor for vomiting or irritability with feeding. Pregnancy (Cat.B). Nursing mothers.

E.e.s. Granules Pharmacokinetics

See Literature

E.e.s. Granules Interactions


See Contraindications. May potentiate theophylline (reduce dose of theophylline), digoxin, oral anticoagulants, hexobarbital, phenytoin, valproate. May potentiate CYP3A substrates (eg, triazolam, midazolam, statins [rhabdomyolysis], sildenafil [reduce dose of sildenafil], colchicine [reduce starting dose of colchicine, max dose should be lowered; monitor], verapamil, amlodipine, diltiazem, carbamazepine, cyclosporine, tacrolimus, alfentanil, disopyramide, bromocriptine, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine); consider dose adjustments and monitor. May be antagonized by theophylline. Hypotension, bradyarrhythmias, lactic acidosis with verapamil. QT prolongation with concomitant Class 1A (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmics; avoid. May interfere with fluorometric detection of urinary catecholamines.

E.e.s. Granules Adverse Reactions

Adverse Reactions

GI upset, abdominal pain, anorexia, hepatic dysfunction; QT prolongation, C. difficile-associated diarrhea, superinfection (discontinue if occurs).

E.e.s. Granules Clinical Trials

See Literature

E.e.s. Granules Note

Not Applicable

E.e.s. Granules Patient Counseling

See Literature