E.e.s. 400 Tablets

  • Bacterial infections

E.e.s. 400 Tablets Generic Name & Formulations

General Description

Erythromycin (as ethylsuccinate) 400mg.

Pharmacological Class


See Also

How Supplied

Granules—100mL, 200mL; Tabs—100

E.e.s. 400 Tablets Indications


Treatment of susceptible infections including upper and lower respiratory, skin and skin structure, genitourinary, Legionnaires' disease, pertussis, listeriosis. Prophylaxis for rheumatic fever attacks in penicillin-allergic patients.

E.e.s. 400 Tablets Dosage and Administration


1.6g/day in 2, 3, or 4 evenly divided doses; max 4g/day. Legionnaires: 1.6–4g/day in divided doses. Prophylaxis: 400mg twice daily. See full labeling.


Mild-to-moderate infections: 30–50mg/kg/day in 2, 3, or 4 evenly divided doses; may double dose in severe infections. See full labeling.

E.e.s. 400 Tablets Contraindications


Concomitant terfenadine, astemizole, cisapride, pimozide, ergotamine, dihydroergotamine, statins (eg, lovastatin, simvastatin).

E.e.s. 400 Tablets Boxed Warnings

Not Applicable

E.e.s. 400 Tablets Warnings/Precautions


Avoid in proarrhythmic conditions (eg, uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia); risk of QT prolongation. Myasthenia gravis. Hepatic impairment. Elderly. Infants: risk of infantile hypertrophic pyloric stenosis; monitor for vomiting or irritability with feeding. Pregnancy (Cat.B). Nursing mothers.

E.e.s. 400 Tablets Pharmacokinetics

See Literature

E.e.s. 400 Tablets Interactions


See Contraindications. May potentiate theophylline (reduce dose of theophylline), digoxin, oral anticoagulants, hexobarbital, phenytoin, valproate. May potentiate CYP3A substrates (eg, triazolam, midazolam, statins [rhabdomyolysis], sildenafil [reduce dose of sildenafil], colchicine [reduce starting dose of colchicine, max dose should be lowered; monitor], verapamil, amlodipine, diltiazem, carbamazepine, cyclosporine, tacrolimus, alfentanil, disopyramide, bromocriptine, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine); consider dose adjustments and monitor. May be antagonized by theophylline. Hypotension, bradyarrhythmias, lactic acidosis with verapamil. QT prolongation with concomitant Class 1A (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmics; avoid. May interfere with fluorometric detection of urinary catecholamines.

E.e.s. 400 Tablets Adverse Reactions

Adverse Reactions

GI upset, abdominal pain, anorexia, hepatic dysfunction; QT prolongation, C. difficile-associated diarrhea, superinfection (discontinue if occurs).

E.e.s. 400 Tablets Clinical Trials

See Literature

E.e.s. 400 Tablets Note

Not Applicable

E.e.s. 400 Tablets Patient Counseling

See Literature