Arthritis/rheumatic disorders:

Indications for DUROLANE:

Symptomatic treatment of mild-to-moderate knee or hip osteoarthritis.


Remove joint effusion before inj. Give as a single intra-articular inj. 3mL per knee or hip. Local anesthetic by SC inj or topical freezing agents may be used prior to inj. Use separate syringes for each joint.


Not studied.


Do not inject by intravascular or extra-articular route, or in the synovial tissues or capsule. Avoid infected or severely inflamed synovial joint, active skin disease or infection at or near inj site. Venous or lymphatic stasis in the leg. Pre-existing chondrocalcinosis. Hyaluronic acid sensitivity. Avoid strenuous activity within 48hrs after injection. Pregnancy, nursing mothers: not studied.

Pharmacologic Class:



Concomitant other intra-articular injectables: not established.

Adverse Reactions:

Transient pain, swelling, joint stiffness; infection.

Generic Availability:


How Supplied:

Single-use prefilled syringe (3mL)—1