• Psoriasis

Duobrii Generic Name & Formulations

General Description

Halobetasol propionate 0.01%, tazarotene 0.045%; lotion.

Pharmacological Class

Corticosteroid + retinoid.

How Supplied


Generic Availability


Duobrii Indications


Plaque psoriasis.

Duobrii Dosage and Administration


≥18yrs: apply a thin layer to affected areas once daily; max 50g/week. Discontinue when control is achieved. Do not occlude. Females of reproductive potential: initiate therapy during normal menses.


<18yrs: not established.

Duobrii Contraindications



Duobrii Boxed Warnings

Not Applicable

Duobrii Warnings/Precautions


Not for oral, ophthalmic, or intravaginal use. Avoid use on the face, groin, or axillae. Risk of HPA axis suppression with high-potency corticosteroids, application to large surface areas, occlusive use, altered skin barrier, concomitant multiple corticosteroid-containing products, liver failure, young age; discontinue gradually or reduce dose, if occurs. Avoid use on eczematous or sunburned skin. Sun sensitivity. Increased risk of posterior subcapsular cataracts and glaucoma; monitor for visual symptoms. Treat infection if present or develops; discontinue until resolved. Reevaluate periodically. Embryo-fetal toxicity. Obtain reliable negative pregnancy test within 2wks before initiating therapy. Advise females of reproductive potential to use effective contraception during therapy. Nursing mothers: avoid direct infant exposure.

Duobrii Pharmacokinetics

See Literature

Duobrii Interactions


Caution with photosensitizers (eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides).

Duobrii Adverse Reactions

Adverse Reactions

Contact dermatitis, application site pain, folliculitis, skin atrophy, excoriation, rash, skin abrasion/exfoliation; local adverse reactions (eg, striae, telangiectasias), Cushing’s syndrome, hyperglycemia, glucosuria, HPA axis suppression (esp. in children).

Duobrii Clinical Trials

See Literature

Duobrii Note

Not Applicable

Duobrii Patient Counseling

See Literature