Donnatal Elixir

  • Hyperacidity, GERD, and ulcers

Donnatal Elixir Generic Name & Formulations

General Description

Phenobarbital 16.2mg, hyoscyamine sulfate 0.1037mg, atropine sulfate 0.0194mg, scopolamine HBr 0.0065mg; per 5mL; contains alcohol; grape flavor.

Pharmacological Class

Barbiturate + anticholinergics.

See Also

How Supplied

Tabs—100, 1000; Elixir—4oz, pt

Donnatal Elixir Indications


Adjunct in irritable bowel syndrome, enterocolitis, duodenal ulcer.

Donnatal Elixir Dosage and Administration


5–10mL 3–4 times daily.


<10lb (4.5kg): not recommended. 10lb (4.5kg): Initially 0.5mL every 4hrs or 0.75mL every 6hrs. 20lb (9.1kg): 1mL every 4hrs or 1.5mL every 6hrs. 30lb (13.6kg): 1.5mL every 4hrs or 2mL every 6hrs. 50lb (22.7kg): 2.5mL every 4hrs or 3.75mL every 6hrs. 75lb (34kg): 3.75mL every 4hrs or 5mL every 6hrs. 100 lb (45.4kg): 5mL every 4hrs or 7.5mL every 6hrs.

Donnatal Elixir Contraindications


Glaucoma. Porphyria. Unstable cardiovascular status. GI or GU obstruction. Paralytic ileus or intestinal atony. Toxic megacolon. Severe ulcerative colitis. Myasthenia gravis. Hiatal hernia. History of paradoxical reactions to phenobarbital.

Donnatal Elixir Boxed Warnings

Not Applicable

Donnatal Elixir Warnings/Precautions


Renal or hepatic impairment. Autonomic neuropathy. Cardiovascular disease. Hypertension. Hyperthyroidism. Drug abusers. High environmental temperature. Gastric ulcer. Diarrhea. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers.

Donnatal Elixir Pharmacokinetics

See Literature

Donnatal Elixir Interactions


Potentiated CNS depression with alcohol, other CNS depressants. Additive anticholinergic effects with other anticholinergics, narcotics, type I antiarrhythmics, antihistamines, phenothiazines, tricyclics. May antagonize anticoagulants, CYP450 substrates.

Donnatal Elixir Adverse Reactions

Adverse Reactions

Drowsiness, anticholinergic effects, paradoxical excitement.

Donnatal Elixir Clinical Trials

See Literature

Donnatal Elixir Note

Not Applicable

Donnatal Elixir Patient Counseling

See Literature