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Donepezil Orally Disintegrating Tabs Generic Name & Formulations
Legal Class
Rx
General Description
Donepezil HCl 5mg, 10mg.
Pharmacological Class
Reversible acetylcholinesterase inhibitor (piperidine deriv).
See Also
How Supplied
Tabs 5mg, 10mg—30, 90; 23mg—30; ODT—contact supplier
Manufacturer
Donepezil Orally Disintegrating Tabs Indications
Indications
Alzheimer's dementia.
Donepezil Orally Disintegrating Tabs Dosage and Administration
Adult
Tabs: Swallow whole with water. ODT: dissolve on tongue, follow with water. Mild-to-moderate: Initially 5mg daily at bedtime, may increase to max 10mg daily after 4–6 weeks; usual dose: 5mg or 10mg once daily. Moderate-to-severe: initially 5mg daily at bedtime, may increase to 10mg daily after 4–6 weeks; may further increase to max 23mg daily after 3 months; usual dose: 10mg or 23mg once daily.
Children
Not established.
Donepezil Orally Disintegrating Tabs Contraindications
Not Applicable
Donepezil Orally Disintegrating Tabs Boxed Warnings
Not Applicable
Donepezil Orally Disintegrating Tabs Warnings/Precautions
Warnings/Precautions
Cardiac conduction conditions. Peptic ulcer. Monitor for GI bleeding. Seizures. Asthma or COPD. GU obstruction. Body weight <55kg. Pregnancy. Nursing mothers.
Donepezil Orally Disintegrating Tabs Pharmacokinetics
See Literature
Donepezil Orally Disintegrating Tabs Interactions
Interactions
Drugs that affect CYP2D6 and CYP3A4 may affect rate of elimination. Antagonizes anticholinergics. May potentiate succinylcholine-type muscle relaxants, other cholinesterase inhibitors, cholinergic agonists (eg, bethanecol). Concomitant NSAIDs may increase risk of GI bleed.
Donepezil Orally Disintegrating Tabs Adverse Reactions
Adverse Reactions
Nausea, diarrhea, vomiting, insomnia, muscle cramps, fatigue, anorexia, weight loss (esp. using 23mg/day dose).
Donepezil Orally Disintegrating Tabs Clinical Trials
See Literature
Donepezil Orally Disintegrating Tabs Note
Not Applicable
Donepezil Orally Disintegrating Tabs Patient Counseling
See Literature
