Donepezil Orally Disintegrating Tabs

— THERAPEUTIC DISORDERS TREATED —
  • Alzheimer's dementia

Donepezil Orally Disintegrating Tabs Generic Name & Formulations

General Description

Donepezil HCl 5mg, 10mg.

Pharmacological Class

Reversible acetylcholinesterase inhibitor (piperidine deriv).

See Also

How Supplied

Tabs 5mg, 10mg—30, 90; 23mg—30; ODT—contact supplier

Donepezil Orally Disintegrating Tabs Indications

Indications

Alzheimer's dementia.

Donepezil Orally Disintegrating Tabs Dosage and Administration

Adult

Tabs: Swallow whole with water. ODT: dissolve on tongue, follow with water. Mild-to-moderate: Initially 5mg daily at bedtime, may increase to max 10mg daily after 4–6 weeks; usual dose: 5mg or 10mg once daily. Moderate-to-severe: initially 5mg daily at bedtime, may increase to 10mg daily after 4–6 weeks; may further increase to max 23mg daily after 3 months; usual dose: 10mg or 23mg once daily.

Children

Not established.

Donepezil Orally Disintegrating Tabs Contraindications

Not Applicable

Donepezil Orally Disintegrating Tabs Boxed Warnings

Not Applicable

Donepezil Orally Disintegrating Tabs Warnings/Precautions

Warnings/Precautions

Cardiac conduction conditions. Peptic ulcer. Monitor for GI bleeding. Seizures. Asthma or COPD. GU obstruction. Body weight <55kg. Pregnancy. Nursing mothers.

Donepezil Orally Disintegrating Tabs Pharmacokinetics

See Literature

Donepezil Orally Disintegrating Tabs Interactions

Interactions

Drugs that affect CYP2D6 and CYP3A4 may affect rate of elimination. Antagonizes anticholinergics. May potentiate succinylcholine-type muscle relaxants, other cholinesterase inhibitors, cholinergic agonists (eg, bethanecol). Concomitant NSAIDs may increase risk of GI bleed.

Donepezil Orally Disintegrating Tabs Adverse Reactions

Adverse Reactions

Nausea, diarrhea, vomiting, insomnia, muscle cramps, fatigue, anorexia, weight loss (esp. using 23mg/day dose).

Donepezil Orally Disintegrating Tabs Clinical Trials

See Literature

Donepezil Orally Disintegrating Tabs Note

Not Applicable

Donepezil Orally Disintegrating Tabs Patient Counseling

See Literature