• Addiction/dependence

Disulfiram Generic Name & Formulations

General Description

Disulfiram 250mg, 500mg; tabs.

Pharmacological Class

Alcohol deterrent.

How Supplied

Contact supplier

Disulfiram Indications


Adjunct in management of chronic alcoholic patients who want to remain sober.

Disulfiram Dosage and Administration


Abstain for at least 12hrs. Initially 500mg once daily for 1–2 weeks then 250mg once daily; max 500mg daily. Continue until patient develops basis for self-control.


Not established.

Disulfiram Contraindications


Severe cardiovascular disease. Psychosis. Allergy to thiuram in pesticides and rubber. Concomitant metronidazole, paraldehyde, alcohol-containing products.

Disulfiram Boxed Warnings

Not Applicable

Disulfiram Warnings/Precautions


Never administer when in a state of alcohol intoxication. Advise family members of alcohol effect. Diabetes. Hypothyroidism. Epilepsy. Cerebral damage. Nephritis. Hepatic cirrhosis or insufficiency. Ethylene dibromide inhalation. Monitor hepatic function, electrolytes, blood, CBCs. Alcohol trial in patients >50yrs: not recommended. Pregnancy. Nursing mothers.

Disulfiram Pharmacokinetics

See Literature

Disulfiram Interactions


See Contraindications. Alcohol-like reaction to metronidazole, paraldehyde, alcohol-containing drugs and elixirs, some so-called alcohol-free beverages, tonics, foods, aftershave, back rubs. Potentiates phenytoin, oral anticoagulants, isoniazid.

Disulfiram Adverse Reactions

Adverse Reactions

Optic, peripheral and polyneuritis; peripheral neuropathy, drowsiness, rash, psychosis, hepatitis.

Disulfiram Clinical Trials

See Literature

Disulfiram Note


Formerly known under the brand name Antabuse.

Disulfiram Patient Counseling

See Literature